얇은 막 수화법을 이용한 니오좀의 제조 및 특성 = Preparation and Properties of Niosomes by Thin Film Hydration Method

다국어 초록 (Multilingual Abstract)

Niosomes are lamellar structures, which are formed on the admixture of non-ionic surfactant of the alkyl or dialkyl polyglycerol ether group and cholesterol by thin film hydration method. We prepared collagen-encapsulated niosomes to increase the absorption rate of the collagen to the skin. In this experiment, we used polyoxyethylene sorbitan and cholesterol to prepare niosomes, and we chose fish scale collagen as encapsulating drug. To characterize of niosomes, we used particle size analyzer, UV-Vis spectrometer, scanning electron microscope. As a result, niosome size was increased with the concentration of cholesterol. Encapsulation efficiency of niosomes was different according to the content ratio of cholesterol and the kind of non-ionic surfactant. Niosome stability was excellent at 4℃.