초음파 결합 마이크로니들 시스템을 통한 진정 및 재생 활성성분 경피전달 = Transdermal Delivery of Calming and Rejuvenating Active Ingredients through Ultrasonic Coupling Microneedle System

다국어 초록 (Multilingual Abstract)

The beauty treatment industry has been growing worldwide since the 2000s. However, despite this progress, research and post-treatment care for the pain and side effects caused by beauty care treatments have been lagging behind. This study proposes a new device that combines the advantages of the Dissolving Microneedle Channeling System and ultrasonic treatment. Dissolving Microneedle Channeling System and ultrasonic treatment have been developed to overcome the drawbacks of conventional treatments such as laser skin resurfacing and Microneedling Therapy Systems (MTS). To address the disadvantages of Dissolving Microneedle Channeling System and ultrasonic treatment, a Sucralfate 0.5% and Vitamin K 3% solution is applied to the Dissolving Microneedle Channeling System, which is known as KS-DMCS, to facilitate wound healing caused by the microneedles. Additionally, an external serum (Ceutisome Serum) containing liquid oxygen cosmetics is used to activate skin cells. Experimental results confirm that the combination of ultrasonic treatment and Dissolving Microneedle Channeling System demonstrates significant improvement. The feasibility test confirms the stability of the Sucralfate 0.5% and Vitamin K 3% solution with the needle array. It is also confirmed that the serum, which contains liquid oxygen cosmetics, diffuses to the target depth without interference from the Sucralfate 0.5% and Vitamin K 3% solution. Therefore, the combination of ultrasonic treatment and Dissolving Microneedle Channeling System exhibits a better delivery effect compared to using Dissolving Microneedle Channeling System or ultrasonic treatment alone, successfully delivering each active ingredient to the desired depth. This study proposes this combination as an innovative strategy for a system that enhances the efficacy of skincare and facilitates the delivery of active ingredients without causing pain or side effects to the user.

국문 초록 (Abstract)

미용치료 산업은 2000년대부터 전 세계적으로 성장해 왔다. 그러나 이러한 발전에도 불구하고 미용 시술로 인한 통증과 부작용에 대한 연구와 사후 관리는 뒤쳐져 왔다. 본 연구는 용해 마이크로니들 채널링 시스템과 초음파 처리의 장점을 결합한 새로운 장치를 제안하는데 그 목적이 있다. 레이저 피부미용 시술(Skin LASER) 및 마이크로니들링 테라피 시스템(MTS)과 같은 기존 치료법의 단점을 극복하기 위해 용해 마이크로니들링 시스템과 초음파 치료법이 개발되었다. KS-DMCS로 알려진 용해성 마이크로니들 채널링 시스템에는 용해성 마이크로니들 채널링 시스템과 초음파 처리의 단점을 해결하기 위해 수크랄페이트 0.5%와 비타민 K 3% 용액을 적용하여 마이크로니들에 의한 상처 치유를 용이하게 한다. 또한, 액체 산소 화장품이 함유된 외부 세럼(Ceutisome Serum)을 사용하여 피부 세포를 활성화한다. 실험 결과 초음파 처리와 용해 마이크로니들 채널링 시스템의 조합이 상당한 개선을 나타냄을 확인하였으며, 타당성 테스트를 통해 마이크로 니들과 Sucralfate 0.5% 및 Vitamin K 3% 혼합 용액과 서로 반응치 않는 안정성을 확인하였다. 또한 액체산소가 함유된 세럼이 Sucralfate 0.5% 및 Vitamin K 3% 혼합 용액과 간섭 반응성 없이 목표 깊이까지 확산되는 것을 확인할 수 있었다. 따라서 초음파 처리와 용해 마이크로니들 채널링 시스템의 조합은 용해 마이크로니들 채널링 시스템을 단독으로 사용하거나 초음파 처리를 단독으로 사용하는 경우보다 더 나은 경피전달 효과를 보이며, 각 활성 성분을 원하는 깊이까지 성공적으로 전달할 수 있다. 본 연구에서는 이러한 조합을 사용자에게 통증이나 부작용을 주지 않으면서 스킨케어의 효능을 높이고 유효성분의 전달을 용이하게 하는 시스템을 위한 혁신적인 전략으로 제안하고자 한다.

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