급성말초전정병변 후 전정보상과정 중 전정안반사 운동 학습능력 변화 = VOR motor learning during vestibular compensation

다국어 초록 (Multilingual Abstract)

The vestibulo-ocular reflex (VOR) is a very useful tool for researchers who study motor learning and memory because of its various strengths. For this reason, we recently developed a PC-based eye tracking system for measuring VOR in mice. To test the reliability of the system and have knowledge of dynamic characteristics in response to vesibular and optical stimulus in mice, the VOR, optokinetic response (OKR), and their interaction were investigated in the mouse using video oculography technique.We used 7 week-old C57BL/6 male mice for this test. Behavioral test was operated using self-designed turn-table machine. The dark vestibulo-ocular reflex (dVOR) and light vesibulo-ocular reflex (lVOR) were induced by sinusoidal rotation of a turntable, in darkness and in light, respectively, by 5° (peak to peak) at 0.2, 0.4, 0.6, 0.8, 1.0 Hz. The OKR was induced by sinusoidal rotation of a dot-patterned screen by same amplitude over the tested frequency range. The gain and phase of the response were calculated from the acquired data by using customized analysis tool written by LabVIEW. Gain is defined as the ratio of output to input, that is, ratio of eye velocity to table velocity, or head velocity. Phase is defined as the time gap between two peak points of eye and head movement.The response of the dVOR showed a higher gain and smaller phase lead as stimulus velocity increased. The response of the lVOR was nearly constant gain and phase over whole frequency range we tested. The response of the OKR revealed a lower gain and bigger phase lag when stimulus velocity increased. We also induced VOR learning and observed the increase of gain which was lasted for 7 hours. We successfully measured the horizontal eye movement during vestibular and optical stimuli in C57BL/6 mice, and These results were consistent with findings from literature.

국문 초록 (Abstract)

암시야에서 전정안반사를 측정하였을 경우, 테이블의 회전 속도가 증가할수록 gain은 증가하고, phase lead는 감소하였다. 그러나 명시야에서 전정안반사를 측정하였을 경우, 테이블의 회전속도와 무관하게 일정한 gain과 phase결과를 보임