급성기 뇌졸중 환자에서 Brain Natriuretic Peptide가 갖는 예후 인자적 가치 = Prognistic Value of Brain Natriuretic Peptide on Patients Acute Phase of Stroke

다국어 초록 (Multilingual Abstract)

Background: Brain Natriuretic Peptide (BNP) Brain natriuretic peptides (BNP) has provided prognostic information in various patient populations especially in heart failure and coronary syndromes. However, the prognostic value of BNP among patients with acute stroke remains unclear, although elevated peptide levels have occasionally been observed. We measured plasma BNP at admission in acute ischemic stroke patients without evident cardiac disease. We compaired the relationship between plasma BNP level and the course of clinical neurological deficits.
Methods : A series of 75 patients (mean age, 64.0 ± 11.0 years) in acute ischemic stroke without evident cardiac disease underwent a comprehensive clinical examination and measurements of plasma BNP at admission in the acute phase of stroke. The relation of laboratory values to risk factors for all-cause mortality, stroke subtype classification, clinical course, and outcome after 30 days were analyzed. Control group was consisted of 31 subjects without neurological focal deficits.
Results : Plasma concentrations of BNP (124.7 ± 209.1 pg/ml) in the stroke patients were significantly higher than those of the healthy subjects (39.1 ± 27.7 pg/ml, P <0.018, respectively). The proportion of patients with bad outcome was increased significantly in the group with high BNP level. Using univariate regression analysis, significant relation of BNP to morbidity and mortality found in acute ischemic stroke patients.
Conclusion : Plasma levels of BNP were elevated in the acute phase of stroke and predict clinical outcome including poststroke mortality.

목차 (Table of Contents)

• 서론
• 연구 대상 및 방법
• 1. 연구대상
• 2. 연구방법
• 3. 통계분석
• 결과
• 1. 뇌경색 환자군의 임상적 특징
• 2. 사망률과 임상경과
• 고찰
• 결론
• 참고문헌

참고문헌 (Reference)

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