Parlodel ( Ergocriptine, CB 154 ) 의 유즙분비 억제효과 = Parlodel in Inhibition of Puerperal Lactation

다국어 초록 (Multilingual Abstract)

Therapeutic efficacy of parlodel, CB 154, in prevention and suppression of lactation has been evaluated in 50 puerperal women. The total number of women comprised 32 cases of prevention of postpartum lactation and 18 cases of suppression of established lactation. Medication was started 4 to 6 hours after delivery in the prevention group and as soon as the decision was made in the suppression group, lasting for 14 days in both. Methods of medication were designed in two different wasys to evaluate whether or no differences in the efficacy and rebound reaction between them, the one is simple method taking 2.5mg parlodel tablet twice daily and the other is tapering method having 2.5mg three times a day for the first 5 days and 2.5mg twice a day for the next 4 days and once a day for the last 5 days. The radioimmunoassay of serum prolactin (hPRL) values in 6 parlodel treated women were so impressive as to fall rapidly down to the normal levels. Fig. 1 demonstrates the postpartum changes of hPRL values in parlodel treated cases and nursing women. Criteria of clinical evaluation were the degree of breast engorgement, pain, milk secreation and rebound engorgement. The drug effectiveness were excellent and were thought to be superior to any other conventional methods of treatment revealing about 90% scored Good and about 10% were Fair regardless of preventation and suppression, method of medication, parity, type of delivery and history of previous suppression. 14 out of 50 cases (28%) showed rebound reaction but they passed through spontaneously without additional medication. The frequency of rebound milk secretion was found to be more common among the patients treated for prevention of postpartum lactation than among those treated for suppression of established engorgement of the breast. Hemodynamic studies and laboratory tests of blood and urine carried out during and after the treatment remained within normal limits and uterine involution of parlodel treated cases showed no difference from normal nonmedicated puerpe