Effect of water-soluble propolis administration on the ethanol-induced hangover in rats

다국어 초록 (Multilingual Abstract)

Water soluble propolis was prepared using b–cyclodextrin, and its effect on an ethanol-induced hangoverwas examined in Sprague–Dawley (SD) rats fed withethanol. When SD rats were administrated with propolis30 min after ethanol feeding, ethanol content in the ratserum decreased 2.1 times 1 h after ethanol feeding.
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase(ALDH) activity in rat liver increased 3.0 and 4.4times, respectively, 1 h after ethanol feeding and administrationof propolis 30 min after ethanol feeding. Therewere no differences in the expression of ADH and ALDHgenes regardless of propolis administration. These resultsindicated that a decrease in ethanol content in the serumwas not due to an increase in the expression of ADH orALDH genes but rather, an increase in activities of ADHand ALDH.

참고문헌 (Reference)

1 조연옥, "차나무(Camellia sinensis) 추출물이 아급성 알코올 투여 마우스의 항산화 및 알코올 분해 효소 활성에 미치는 영향" 한국식품영양과학회 36 (36): 1134-1139, 2007

2 부희옥, "여주 품종별 폴리페놀, 플라보노이드 함량과 라디칼 소거활성 및 아질산염 소거능" 한국약용작물학회 17 (17): 15-20, 2009

3 홍인표, "약용버섯을 이용한 도토리화분의 세포 발아 및 항산화 활성" 한국균학회 42 (42): 165-169, 2014

4 정용준, "발효한약추출물 HP-1이 알코올을 투여한 쥐의 알코올 대사에 미치는 영향" 한의병리학회 21 (21): 387-391, 2007

5 Verster JC, "Treatment and prevention of alcohol hangover" 3 : 103-109, 2013

6 Wiese JG, "The alcohol hangover" 132 : 897-902, 2000

7 Na-Hyun Kim, "The Extract of Limonium tetragonum Protected Liver against Acute Alcohol Toxicity by Enhancing Ethanol Metabolism and Antioxidant Enzyme Activities" 한국생약학회 21 (21): 54-58, 2015

8 Burdock GA, "Review of the biological properties and toxicity of bee propolis(propolis)" 36 : 347-363, 1998

9 Yang HJ, "Red mulberry fruit aqueous extract and silk protein accelerate acute ethanol metabolism and promote the anti-oxidant enzyme systems in rats" 18 : 1197-1205, 2018

10 Bankova V, "Propolis : recent advances in chemistry and plant origin" 31 : 3-15, 2000

11 Marcucci MC, "Propolis : chemical composition, biological properties and therapeutic activity" 26 : 83-99, 1995

12 Isla MI, "Physico chemical and bioactive properties of honeys from Northwestern Argentina" 44 : 1922-1930, 2011

13 Falca˜o SI, "Phenolic characterization of Northeast Portuguese propolis : usual and unusual compounds" 396 : 887-897, 2010

14 Jo¨rnvall H, "Origin and evolution of medium chain alcohol dehydrogenases" 202 : 91-96, 2013

15 Salatino A, "Origin and chemical variation of Brazilian propolis" 2 : 33-38, 2005

16 Prat G, "Neurocognitive effects of alcohol hangover" 33 : 15-23, 2008

17 Pittler MH, "Interventions for preventing or treating alcohol hangover : systematic review of randomised controlled trials" 331 : 1515-1518, 2005

18 Srinivasan S, "Influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities" 1 : 8-16, 2019

19 Duca A, "Identification of resveratrol as bioactive compound of propolis from Western Romania and characterization of phenolic profile and antioxidant activity of ethanolic extracts" 24 : 3368-, 2019

20 Yin SJ, "Human stomach alcohol and aldehyde dehydrogenases : comparison of expression pattern and activities in alimentary tract" 112 : 766-775, 1997

21 Shi P, "Honey reduces blood alcohol concentration but not affects the level of serum MDA and GSH-Px activity in intoxicated male mice models" 15 : 225-, 2015

22 Calder I, "Hangovers" 314 : 2-3, 1997

23 Piasecki TM, "Hangover frequency and risk for alcohol use disorders : evidence from a longitudinal high-risk study" 114 : 223-234, 2005

24 Viuda-Martos M, "Functional properties of honey, propolis, and royal jelly" 73 : R117-R124, 2008

25 Li L, "Fructose 1, 6–diphosphate prevents alcohol–induced liver injury through inhibiting oxidative stress and promoting alcohol metabolism in mice" 815 : 274-281, 2017

26 He L, "Ethanol induction of class I alcohol dehydrogenase expression in the rat occurs through alterations in CCAAT/enhancer binding proteins b and c" 277 : 43572-43577, 2002

27 Anderson SM, "Ethanol consumption and hepatic enzyme activity" 11 : 83-88, 1979

28 Chang CC, "Estimation of total flavonoid content in propolis by two complementary colorimetric methods" 10 : 178-182, 2002

29 서지연, "Enhancement of Alcohol Metabolism by Sprouted Peanut Extract in SD Rats" 한국식품영양과학회 19 (19): 1-4, 2014

30 Loguercio C, "Effect of alcohol abuse and glutathione administration on the circulating levels of glutathione and on antipyrine metabolism in patients with alcoholic liver cirrhosis" 56 : 441-447, 1996

31 Simo˜es LMC, "Effect of Brazilian green propolis on the production of reactive oxygen species by stimulated neutrophils" 94 : 59-65, 2004

32 Yoon M, "Developmental expression of aldehyde dehydrogenase in rat : a comparison of liver and lung development" 8 : 386-398, 2005

33 Meda A, "Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity" 91 : 571-577, 2005

34 Moreno MIN, "Comparison of the free radical-scavenging activity of propolis from several regions of Argentina" 71 : 109-114, 2000

35 Yamasaki K, "Chronic intake of high–dose of blueberry leaf extract does not augment the harmful effects of ethanol in rats" 7 : e6989-, 2019

36 Silici S, "Chemical composition and antibacterial activity of propolis collected by three different races of honeybees in the same region" 99 : 69-73, 2005

37 Siripatrawan U, "Antioxidant and antimicrobial properties of Thai propolis extracted using ethanol aqueous solution" 48 : 22-27, 2013

38 Prat G, "Alcohol hangover : a critical review of explanatory factors" 24 : 259-267, 2009

39 Swift R, "Alcohol hangover : Mechanisms and mediators" 22 : 54-60, 1998

40 Jelski W, "Alcohol dehydrogenase(ADH)and aldehyde dehydrogenase(ALDH)in the cancer diseases" 395 : 1-5, 2008

41 Foster WH, "Absenteeism and business costs : does substance abuse matter? J" 28 : 27-33, 2005