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      KCI등재 SCOPUS SCIE

      1,2-Dimethylhydrazine에 의해 유발된 Colonic Aberrant Crypt Foci에 대한 마늘추출물의 암예방효과 = Chemopreventive Effects of Garlic Extracts on Rat Colonic Aberrant Crypt Foci Induced by 1,2-Dimethylhydrazine

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      https://www.riss.kr/link?id=A76271740

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      다국어 초록 (Multilingual Abstract)

      Garlic (Allium sativum L.) with the food supplement material and medicine was used traditionally in Asia and Europe. Epidemiological studies revealed that the intake of garlic reduced incidences of various cancer including digestive system. The present study was designed to investigate the effect of garlic ethanol extract on the development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH) in male F344 rats. Five-week-old rats were given four times for two weeks to subcutaneous injections by DMH (30 ㎎/㎏ body weight) to induce ACF. The animals were divided into groups that fed diet containing garlic ethanol extract at five different doses (0.1, 0.2, 0.5, 2, 5%), respectively, animals were evaluated for the total number of ACF and total aberrant crypts (AC) per colon detected from methylene blue-stained rat colon. ACF were formed in animals in DMH-treated group. The feeding suppressed potently the appearance ACF in the colon of rats. Especially, fed diet containing garlic ethanol extract at intermediate dose (0.5%) significantly reduced the number of ACF and AC per colon (p < 0.05). Garlic ethanol extract inhibited DMH-induced overexpression of Activator Protein-1 (AP-1) and β-catenin genes related to cell proliferation that also upregulated the expression of p21Waf1/Cip1 mRNA, a cell cycle-regulating gene. These results suggested that garlic ethanol extract may inhibit ACF formation, β-catenin gene as the early preneoplastic marker of malignant potential in the process of colon carcinogenesis.
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      Garlic (Allium sativum L.) with the food supplement material and medicine was used traditionally in Asia and Europe. Epidemiological studies revealed that the intake of garlic reduced incidences of various cancer including digestive system. The presen...

      Garlic (Allium sativum L.) with the food supplement material and medicine was used traditionally in Asia and Europe. Epidemiological studies revealed that the intake of garlic reduced incidences of various cancer including digestive system. The present study was designed to investigate the effect of garlic ethanol extract on the development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH) in male F344 rats. Five-week-old rats were given four times for two weeks to subcutaneous injections by DMH (30 ㎎/㎏ body weight) to induce ACF. The animals were divided into groups that fed diet containing garlic ethanol extract at five different doses (0.1, 0.2, 0.5, 2, 5%), respectively, animals were evaluated for the total number of ACF and total aberrant crypts (AC) per colon detected from methylene blue-stained rat colon. ACF were formed in animals in DMH-treated group. The feeding suppressed potently the appearance ACF in the colon of rats. Especially, fed diet containing garlic ethanol extract at intermediate dose (0.5%) significantly reduced the number of ACF and AC per colon (p < 0.05). Garlic ethanol extract inhibited DMH-induced overexpression of Activator Protein-1 (AP-1) and β-catenin genes related to cell proliferation that also upregulated the expression of p21Waf1/Cip1 mRNA, a cell cycle-regulating gene. These results suggested that garlic ethanol extract may inhibit ACF formation, β-catenin gene as the early preneoplastic marker of malignant potential in the process of colon carcinogenesis.

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      목차 (Table of Contents)

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      • 참고문헌
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      참고문헌 (Reference)

      1 Barone, "synthesis and kinetics of activity of the antiChemopreventiveEffects of Garlic Extracts on Rat Colonic Aberrant Crypt Foci 329candidal component of Allium sativum and a hypothesisfor its mode of action" 713-825, 1977

      2 Ocker, M, "The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro" 107 : 453-459, 2003

      3 Block, "The organosulfur chemistry of genus Alliumimplicationsfor the organic chemistry of sulfur" 1135-1178, 1992

      4 Albrecht, C, "Signal transduction pathways relevant for neoplastic effects of fibrous and non-fibrous particles" 553 : 23-35, 2004

      5 Bird, R.P, "Role of aberrant crypt foci in understanding the pathogenesis of colon cancer" 93 : 55-71, 1995

      6 Manna, S.K, "Resveratrol suppresses TNF-induced activatin of nuclear transcription factors NF-κB, Activator protein-1 and apoptosis: Potential role of reactive oxygen intermediates and lipid peroxidation" 164 : 6509-6519, 2000

      7 Kwon, S.K, "Organosulfur compounds from Allium sativum and physiological activities" 11 : 8-32, 2003

      8 Femia, A.P, "Mucin-depleted foci have β-catenin gene mutations, altered expression of its protein, and are dose- and time-dependent in the colon of 1,2-dimethylhydrazine-treated rats" 116 : 9-15, 2005

      9 Corpet, D.E, "Most effective colon cancer chemopreventive agents in rats: a systematic review of aberrant crypt foci and tumor data, ranked by potency" 43 : 1-21, 2002

      10 Chung, J.G, "Inhibition of N-acetyltransferase activity and gene expression in human colon cancer cell lines by diallyl sulfide" 42 : 195-202, 2004

      1 Barone, "synthesis and kinetics of activity of the antiChemopreventiveEffects of Garlic Extracts on Rat Colonic Aberrant Crypt Foci 329candidal component of Allium sativum and a hypothesisfor its mode of action" 713-825, 1977

      2 Ocker, M, "The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro" 107 : 453-459, 2003

      3 Block, "The organosulfur chemistry of genus Alliumimplicationsfor the organic chemistry of sulfur" 1135-1178, 1992

      4 Albrecht, C, "Signal transduction pathways relevant for neoplastic effects of fibrous and non-fibrous particles" 553 : 23-35, 2004

      5 Bird, R.P, "Role of aberrant crypt foci in understanding the pathogenesis of colon cancer" 93 : 55-71, 1995

      6 Manna, S.K, "Resveratrol suppresses TNF-induced activatin of nuclear transcription factors NF-κB, Activator protein-1 and apoptosis: Potential role of reactive oxygen intermediates and lipid peroxidation" 164 : 6509-6519, 2000

      7 Kwon, S.K, "Organosulfur compounds from Allium sativum and physiological activities" 11 : 8-32, 2003

      8 Femia, A.P, "Mucin-depleted foci have β-catenin gene mutations, altered expression of its protein, and are dose- and time-dependent in the colon of 1,2-dimethylhydrazine-treated rats" 116 : 9-15, 2005

      9 Corpet, D.E, "Most effective colon cancer chemopreventive agents in rats: a systematic review of aberrant crypt foci and tumor data, ranked by potency" 43 : 1-21, 2002

      10 Chung, J.G, "Inhibition of N-acetyltransferase activity and gene expression in human colon cancer cell lines by diallyl sulfide" 42 : 195-202, 2004

      11 Klipstein-Grobusch, K, "Influence of lifestyle on the use of supplements in the Brandenburg nutrition and cancer study" 37 : 38-46, 1998

      12 Chang, F, "Implications of the p53 tumor-suppressor gene in clinical oncology" 13 : 1009-1022, 1995

      13 A, "Immunohistochemicaldemonstration of mutant p53 tumour suppressor geneproduct in aberrant crypt foci" 73-88, 1993

      14 Kolligs, F.T, "ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation" 1 : 145-155, 2002

      15 Hudson, E.A, "Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line" 3 : 2-18, 2003

      16 Takahashi, M, "Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents" 95 : 475-480, 2004

      17 Challier, B, "Garlic, onion and cereal fibre as protective factors for breast cancer: a French case-control study" 14 : 737-747, 1998

      18 Fleischauer, A.T, "Garlic consumption and cancer prevention: meta-analyses of colorectal and stomach cancers" 72 : 1047-1052, 2000

      19 Fleischauer, A.T, "Garlic and cancer: a critical review of epidemiologic literature" 131 : 1032S-1040S, 2001

      20 Druesne, N, "Diallyl disulfide (DADS) increases histone acetylation and p21waf1/cip1 expression in human colon tumor cell lines" 25 : 1227-1236, 2004

      21 Korinek, V, "Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma" 275 : 1784-1787, 1997

      22 Han, B.S, "Chemopreventive effects of chitosan on rat colon carcinogenesis induced by azoxymethane." 5 : 29-34, 2001

      23 Kweon, S.H, "Chemopreventive effect of garlic powder diet in diethylnitrosamineinduced rat hepatocarcinogengesis" 73 : 2515-2526, 2003

      24 Kim, D.J, "Chemopreventive effect of 2-(allylthio)pyrazine (2-AP) on rat colon carcinogenesis induced by azoxymethane (AOM)" 166 : 125-133, 2001

      25 Kim, D.J, "Chemoprevention of colon cancer by Korean food plant components" 523 (523): 99-107, 2003

      26 Grana, X, "Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinase (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CDKIs)" 11 : 211-219, 1995

      27 Surh, Y.J, "Cancer chemoprevention with dietary phytochemicals" 3 : 711-780, 2003

      28 Aberle, H, "Cadherincatenin complex: protein interactions and their implications for cadherin function" 61 : 514-523, 1996

      29 Dong, "Blocking of tumor promoter-inducedAP-1 activity inhibits induced transformation in JB6 mouseepidermal cells" 609-613, 1994

      30 Wong, N.A, "Beta-catenin: a linchpin in colorectal carcinogenesis?" 160 : 389-401, 2002

      31 Morin, P.J, "Beta-catenin signaling and cancer" 21 : 1021-1030, 1999

      32 Hirose, Y, "Azoxymethane-induced beta-catenin accumulated crypts in colonic mucosa of rodents as an intermediate biomarker for colon carcinogenesis" 24 : 107-111, 2003

      33 Kitagawa, M, "An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin" 18 : 2401-2410, 1999

      34 Oommen, S, "Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells" 485 : 97-103, 2004

      35 O’Gara, E.A, "Activities of garlic oil, garlic powder and their diallyl constituents against Helicobacter pylori" 20 : 14-18, 2000

      36 Vogelstein, B, "Activation of β- catenin-Tcf signaling in colon cancer by mutations in β- catenin or APC" 275 : 1787-1789, 1997

      37 Mori, H, "Aberrant crypt foci and β-catenin accumulated crypts; significance and roles for colorectal carcinogenesis" 566 : 191-208, 2004

      38 Eferl, R, "AP-1: a double edged sword in tumorigenesis" 3 : 859-868, 2003

      39 통계청, "2003년 사망원인통계결과" 통계청 2004

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2010-06-22 학술지명변경 외국어명 : Journal of Toxicology and Public Health -> Toxicological Research KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2005-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2004-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2002-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.44 0.44 0.36
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.32 0.31 0.707 0.1
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