Uterine papillary serous carcinoma(UPSC) is a rare and highly malignant form of adenocarcinoma of the endometrium. Recently, a highly malignant variant of endometrial carcinoma, called uterine papillary serous carcinoma, has been described by Hendrick...
Uterine papillary serous carcinoma(UPSC) is a rare and highly malignant form of adenocarcinoma of the endometrium. Recently, a highly malignant variant of endometrial carcinoma, called uterine papillary serous carcinoma, has been described by Hendrickson et al. It is similar both cytologically and histologically to ovarian epithelial neoplasms and has a poor prognosis even in early stage disease. Deep myometrial invasion and vascular and lymphatic space involvement are frequently identified in hysterectomy specimens. In view of the poor prognosis of this disease entity, a means of estimating the likelihood for extrauterine metastases preoperatively and of monitoring the disease status of patients during and after therapy would be advantageous.
Newer approaches will be needed to treat this biologically aggressive uterine cancer which has usually spreaded beyond the uterus at the time of diagnosis. Our experience, particularly with the uterine papillary serous carcinoma associated with metastasis to both ovaries, and salpinges, is given and the literatures were reviewed briefly.