Atorvastatin 사용과 연관된 길랑-바레 증후군 1예 = Atorvastatin-induced Guillain-Barre Syndrome - A Case Report -

다국어 초록 (Multilingual Abstract)

The Guillain-Barre syndrome is most frequently triggered by infection, vaccination, surgical treatment, or
malignancy, but unusually occurred by statin therapy.
A 68-year old women who had dyslipidemia during 3-years was admitted to the hospital due to traffic
accident. she had continuously took the medicine (Atorvastatin) for dyslipidema, but recent six months
ago she stopped the medication. After admission for traffic accident, she restarted the medicine for the
second time. Six days later, she suffered drowsy, mental change with motor weakness and sensory change
on both upper and lower limbs. Serum Ig E, cerebrospinal fluid Ig G and protein were increased, but MR
brain images, viral marker, cancer marker did not demonstrate abnormal findings. The electrodiagnostic
studies for diagnosis of Guillain-Barre syndrome showed polyradiculoneuropathy. We stopped a statin
therapy with use of intravenous immunoglobulin. She improved rapidly after treatment.
We report a case of Guillain-Barre syndrome just after taking Atorvastatin, which showed abnormal neurologic
findings inducing progressive motor weakness, sensory change on extremities.

참고문헌 (Reference)

1 Smith AG, "n-Hexane neuropathy due to rubber cement sniffing" 20 : 1445-1450, 1997

2 Gaist D, "Statins and risk of polyneuropathy. A case control study" 58 : 1333-1337, 2002

3 Jeppesen U, "Statins and peripheral neuropathy" 54 : 835-838, 1999

4 Peltier AC, "Reccent advances in drug-induced neuropathies" 15 : 633-638, 2002

5 Giordano N, "Polymyositis associated with simvastatin" 349 : 1600-1601, 1997

6 Liebhaber MI, "Polymyalgia, hypersensitivity penumonitis and other reactions in patients receiving HMG-CoA reductase inhibitors: a report of ten cases" 155 : 886-889, 1999

7 Phan T, "Peripheral neuropathy associated with simvastatin" 58 : 625-628, 1995

8 Hughes RA, "Pathogenesis of Guillain-Barre syndrome" 100 : 74-97, 1999

9 Gherardi RK, "Organic arsenic-induced Guillain-Barre-like syndrome due to melarsoprol: a clinical, electrophysiological and pathological study" 13 : 637-645, 1990

10 Jacobs MB, "HMG-CoA reductase inhibitor therapy and peripheral neuropathy" 120 : 970-, 1994

11 Benito-Leon J, "Guillain-Barre syndrome and allopurinol-induced hypersensitivity" 45 : 186-187, 2001

12 Govoni V, "Epidemiology of the Guillain-Barre syndrome" 14 : 605-613, 2001

13 Fujiwara S, "Diabetic ketoacidosis associated with Guillain-Barre syndrome with autonomic dysfunction" 39 (39): 495-498, 2000

14 Leys D, "Acute polyradiculoneuropathy after amitriptyline overdose" 294 : 608-, 1987