수혈 후 간염 발생을 예방하기 위한 검사법들에 관한 고찰 : C형 간염 중심으로 -- = Evaluation of Laboratory Tests to Prevent Posttransfusion Hepatitis in Donated Blood

국문 초록 (Abstract)

수혈에 의해 발생되는 간염 중 대부분을 차지하고 있는 비A, 비B형 간염을 예방키 위해서 공혈자들에게 실시되고 있는 C형 간염 항체검사의 양성율은 0.49%로서 미국, 일본등 선진국에 비해 결코 높지 않았으며 항체 양성자의 75%는 ALT(SGPT)치가 전상범위 이내였다.

다국어 초록 (Multilingual Abstract)

Recently anti-HCV has become a routine serologic test for blood donors to prevent post-transfusion Non-A, Non-B hepatitis, but some author insisted that anti-HCV demonstrated an etiologic basis for only half of cases of transfusion associated Non-A, Non-B hepatitis.
This study was designed to evaluate the prevalence of each hepatitis marker and understand the correlation between serologic markers for hepatitis B and anti-HCV because it might be helful to understand association of each markers for effective prevention of PTH.
1634 sera were collected from healthy blood donors in Sanggye and Seoul Paik Hospital and tested for HBsAg, anti-HCV, ALT and anti-HBc and results were summarized as follows.
1.Seroprevalence of anti-HCV among blood donors was 0.49%
2.The frequency of anti-HCV increased linearly with the increase of ALT value until 60IU/L (P < 0.05), but ALT values of all anti-HCV positive donors were lower than 60IU/L
3.HBsAg positive rate was 4.77% and ALT values were increased in 15.38% of HBsAg positive donors.
4.2.33% of donors had increased ALT values above 60IU/L irrespective of HBsAg or anti-HCV.
5.Seroprevalence of anti-HBc was 54.1% among donors and correlation between anti-HBc and anti-HCV was not considered.
Above results revealed that the prevalence of anti-HCV was not higher than the one in western countries or Japan and HBsAg was the most prevalent hepatitis marker except anti-HBc still as expected. ALT couldn't become the important surrogate marker for HCV in our country, but it would be necessary to study the increased ALT cases without other hepatitis markers to prevent PTH effectively.

목차 (Table of Contents)

• Ⅰ.서론
• Ⅱ.연구 대상 및 방법
• 1.연구대상
• 2.연구 방법
• Ⅲ.결과
• Ⅳ.고찰
• Ⅴ.맺는말