비만 여성의 유전자 변이 형태에 따른 강도별 운동이 Leptin, Insulin과 LDH·CPK 변화에 미치는 영향 = The Effects of Exercise Intensity by the Type of Gene Mutation of Obese Women on Changes in Leptin, Insulin and LDH-CPK

다국어 초록 (Multilingual Abstract)

Subjects selected for this study were obese middle-aged women aged between 35 and 45 with a BMI of 25 to 30. The subjects were divided into three groups; obese group with no influence of gene mutation, b3 adrenergic receptor gene mutation group and group with two kinds of gene mutations including b3 adrenergic receptor (b3-Ar) and PPAR-g. This study conducted the treadmill walking test on each group at 40~50% HR max ·50~60% HR max and 60~70% HR max about 80 minutes respectively, using a Latin Square design in order to examine the changes in Leptin, Insulin and Plasma LDH & CPK, intending to establish the optimal exercise intensity by cause according to gene type of obesity. The main results of this study were as follow: The Leptin, Insulin, LDH, CPK level showed significant differences in exercise period (p<.001), and also in interaction between exercise period and group (p<.01). The regardless of types and existence of genes and variation of strength of exercise, the walking which is representative of aerobic exercise can solve and protect the obesity.

참고문헌 (Reference)

1 홍기성, "최대운동시 태권도 선수의 CPK와 LDH 동위효소의 변화" 단국대학교 대학원 2003

2 윤영학, "지구성 운동후 혈청 LDH 활성 및 isoenzyme 분포의 변화에 관한 연구" 33-, 1994

3 이회량, "줄넘기 운동이 LDH,CPK 효소 활성에 미치는 영향" 한국교원대학교 대학원 1997

4 최대원, "장기간 트레이닝이 흰쥐의 혈청 LDH 및 CPK 활성도에 미치는 영향" 단 국대학교 대학원. 1998

5 성혜련, "유산소운동이 인슐린 비의존형 당뇨병환자의 혈당 및 면역기능에 미치는 영향" 18 (18): 126-137, 1999

6 김진만, "배드민턴 운동이 여성의 혈중 지질 및 LDH, CPK에 미치는 영향" 서 강대학교 대학원 2001

7 김동희, "달리기 운동이 CPK, LDH 효소 활동에 미치는 영향" 10 : 77-98, 1993

8 "WHO West Pacific Region (2000). The Asia-Pacific Perspective: Redefining Obesity and its Treatment. LOT"

9 Chagnon, Y. C., "The human obesity gene map : the 2000 update" 8 : 89-117, 2000

10 Kohrt, W. M., "Serum leptin levels are reduced in response to exercise training, but not hormone replacement therapy, in older women" 81 : 3980-3985, 1996

11 Considine, R. V., "Serum immunoreactive leptin concertrations in normal weight and obesity humans" 334 : 292-295, 1996

12 Bousser, "Serum enzymes after marathon running" 29 (29): 355-357, 1990

13 Harris, R., "Role of set point theory in regulation of body weight" 4 : 3310-3318, 1990

14 Fan, W., "Role of melanocortinergic neurons in feeding and the agouti obesity syndrome" 358 : 165-168, 1997

15 Akria, H., "Relationship between concentration of serum leptin and fetal growth" 84 (84): 1716-1722, 1997

16 Yiying, "Positional cloning of the mouse obese gene and its human homologue" 372 : 425-432, 1994

17 WHO, "Obesity-preventing and managing the global epidemic: Report of a WHO Consultation on Obesity" 1997

18 Marzo, V., "Leptin regulated endocannabinoids are involved in maintaining food intake" 410 : 822-825, 2001

19 Hickey, M. S., "Leptin is related to body fat content in male distance runners" 271 : 938-940, 1996

20 Seufert, J., "Leptin inhibits insulin gene transcription and reverse hyperinsulinemia in leptin ~deficient ob/ob mice" 96 (96): 674-679, 1999

21 Arner, P., "Hunting for human obesity genes? Look in the adipose tissue!" 4 : 57-62, 2000

22 Marry, A. P., "Effects of obese gene product on body weight regulation on ob/ob mice" 269 : 540-549, 1995

23 Okazaki, T., "Effects of mild aerobic exercise and a mild hypocaloric diet on plasma leptin in sedentary women" 26 (26): 415-420, 1999

24 Shodin, B., "Effect of physical training on LDH activity and LDH isoenzyme pattern in human skeletal muscle" 97 : 150-157, 1996

25 Olive, J. L., "Differential effects of maximal and moderate-intensity runs on plasma leptin in heathly trained subjects" 17 : 365-369, 2001

26 Ryan, A. S., "Changes in plasma leptin and insulin actin with resistance training in postmenopausal women" 24 (24): 27-32, 2000

27 Cardiopulm, "Aerobic endurance exercise of circuit type resistance training for individual with impaired glucose tolerance" 30 (30): 37-41, 1998

28 Wang, J., "A Nutrient~sensing Pathway reguthway regulates leptin gene expression in muscle and fat" 393 : 684-688, 2000