백서에서 estrogen이 급성과 만성의 관절통에 미치는 영향

다국어 초록 (Multilingual Abstract)

Objectives : It is well known that women are more sensitive to pain and have lower threshold than men. The present study was done to investigate whether sex hormones can modulate the pain behaviors and nociceptive activities and also, sex hormones can modulate the morphine antinociceptive activities in acute and chronic arthritis in acute and chronic arthritis.
Materials and Methods : In adults normal female, ovariectomized female and male Sprague-Dawley rats, we induced acute and chronic arthritis using carreginan and CFA repectively. And we compared pain behavior. After that, we investigated morphine analgesia in female and male rat without inducing arthritis. Again, acute and chronic arthritis were induced in each groups and compared morphine analgesia with arthritis.
Results : In acute arthritis, male rats showed significantly reduced weight bearing on affected leg. In contrast to acute declination and recovery of pain pattern in male rats, female rats revealed more gradual and less severe pain pattern. And morphine is more potent in male rats according to reduce mechanical hyperalgesia and male rats were in need small dosage of morphine compared female rats with regard to acute and chronic arthritis.
Conclusions : In conclusion, there were clear sex differences with regard to acute inflammation, and male rats responded more sensitively to morphine. Our results can aid understanding the pain mechanism, treating women who has pain and deciding dosage of analgesic drugs.

Key words : Sex differences, Arthritic pain, Estrogen, Opioids.

목차 (Table of Contents)

• 목 차
• Abstract
• I Introduction
• II. Material and Methods
• III. Results
• IV. Discussion
• V. Conclusion