1 Lianidou ES, "What’s new on circulating tumor cells? A meeting report" 12 : 307-, 2010
2 Fehm T, "Wallwiener D, et al. Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RTPCR and comparison to status of bone marrow disseminated cells" 11 : 59-, 2009
3 Magnifico A, "Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab" 15 : 2010-2021, 2009
4 Bozionellou V, "Trastuzumab administration can effectively target chemotherapy-resistant cytokeratin-19 messenger RNA-positive tumor cells in the peripheral blood and bone marrow of patients with breast cancer" 10 : 8185-8194, 2004
5 Diehn M, "Therapeutic implications of the cancer stem cell hypothesis" 19 : 78-86, 2009
6 Fidler IJ, "The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited" 3 : 453-458, 2003
7 Bustin SA, "The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments" 55 : 611-622, 2009
8 Aktas B, "Stem cell and epithelialmesenchymal transition markers are frequentlyoverexpressed in circulating tumor cells of metastatic breast cancer patients" 11 : 46-, 2009
9 Tibbe AG, "Statistical considerations for enumeration of circulating tumor cells" 71 : 154-162, 2007
10 Pachmann K, "Standardized quantification of circulating peripheral tumor cells from lung and breast cancer" 43 : 617-627, 2005
11 Stathopoulou A, "Real-time quantification of CK-19 mRNA-positive cells in peripheral blood of breast cancer patients using the lightcycler system" 9 : 5145-5151, 2003
12 Slade MJ, "Quantitative polymerase chain reaction for the detection of micrometastases in patients with breast cancer" 17 : 870-879, 1999
13 Cao S, "Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer" 23 : 423-428, 2010
14 Ignatiadis M, "Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancer" 14 : 2593-2600, 2008
15 Xenidis N, "Predictive and prognostic value of peripheral blood cytokeratin- 19 mRNA-positive cells detected by real-time polymerase chain reaction in nodenegative breast cancer patients" 24 : 3756-3762, 2006
16 Lin HK, "Portable filter-based microdevice for detection and characterization of circulating tumor cells" 16 : 5011-5018, 2010
17 Xenidis N, "Peripheral blood circulating cytokeratin-19 mRNApositive cells after the completion of adjuvant chemotherapy in patients with operable breast cancer" 14 : 849-855, 2003
18 Klein CA, "Parallel progression of primary tumours and metastases" 9 : 302-312, 2009
19 Balic M, "Novel immunofluorescence protocol for multimarker assessment of putative disseminating breast cancer stem cells" 19 : 33-40, 2011
20 Balic M, "Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype" 12 : 5615-5621, 2006
21 Tewes M, "Molecular profiling and predictive value of circulating tumor cells in patients with metastatic breast cancer: an option for monitoring response to breast cancer related therapies" 115 : 581-590, 2009
22 Stathopoulou A, "Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic significance" 20 : 3404-3412, 2002
23 Sieuwerts AM, "Molecular characterization of circulating tumor cells in large quantities of contaminating leukocytes by a multiplex real-time PCR" 118 : 455-468, 2009
24 Markou A, "Molecular characterization of circulating tumor cells in breast cancer by a liquidbead array hybridization assay" 57 : 421-430, 2011
25 Punnoose EA, "Molecular biomarker analyses using circulating tumor cells" 5 : 12517-, 2010
26 Fehm T, "Methods for isolating circulating epithelial cells and criteria for their classification as carcinoma cells" 7 : 171-185, 2005
27 Payne RE, "Measurements of EGFR expression on circulating tumor cells are reproducible over time in metastatic breast cancer patients" 10 : 51-57, 2009
28 Nagrath S, "Isolation of rare circulating tumour cells in cancer patients by microchip technology" 450 : 1235-1239, 2007
29 Stott SL, "Isolation of circulating tumor cells using a microvortex-generating herringbone- chip" 107 : 18392-18397, 2010
30 Vona G, "Isolation by size of epithelial tumor cells: a new method for the immunomorphological and molecular characterization of circulating tumor cells" 156 : 57-63, 2000
31 Hayes DF, "Is there a role for circulating tumor cells in the management of breast cancer?" 14 : 3646-3650, 2008
32 Flores LM, "Improving the yield of circulating tumour cells facilitates molecular characterisation and recognition of discordant HER2 amplification in breast cancer" 102 : 1495-1502, 2010
33 Schindlbeck C, "Immunomagnetic enrichment of disseminated tumor cells in bone marrow and blood of breast cancer patients by the Thomsen-Friedenreich- Antigen" 25 : 233-240, 2008
34 Kallergi G, "Hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression in circulating tumor cells of breast cancer patients" 11 : 84-, 2009
35 Adams AA, "Highly efficient circulating tumor cell isolation from whole blood and label-free enumeration using polymer-based microfluidics with an integrated conductivity sensor" 130 : 8633-8641, 2008
36 Ignatiadis M, "HER2-positive circulating tumor cells in breast cancer" 6 : 15624-, 2011
37 Fehm T, "HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trial" 124 : 403-412, 2010
38 Korkaya H, "HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion" 27 : 6120-6130, 2008
39 Meng S, "HER-2 gene amplification can be acquired as breast cancer progresses" 101 : 9393-9398, 2004
40 Alix-Panabières C, "Full-length cytokeratin-19 is released by human tumor cells: a potential role in metastatic progression of breast cancer" 11 : 39-, 2009
41 Kraan J, "External quality assurance of circulating tumor cell enumeration using the CellSearch® system: a feasibility study" 80 : 112-118, 2011
42 Reinholz MM, "Evaluation of a panel of tumor markers for molecular detection of circulating cancer cells in women with suspected breast cancer" 11 : 3722-3732, 2005
43 Becker S, "Evaluation of a RT-PCR based routine screening tool for the detection of disseminated epithelial cells in the bone marrow of breast cancer patients" 117 : 227-233, 2009
44 Liu Z, "Eradication of EGFR-positive circulating tumor cells and objective tumor response with lapatinib and capecitabine" 10 : 860-864, 2010
45 Bonnomet A, "Epithelial-tomesenchymal transitions and circulating tumor cells" 15 : 261-273, 2010
46 Deng G, "Enrichment with anti-cytokeratin alone or combined with anti-EpCAM antibodies significantly increases the sensitivity for circulating tumor cell detection in metastatic breast cancer patients" 10 : 69-, 2008
47 Ignatiadis M, "Different prognostic value of cytokeratin-19 mRNA positive circulating tumor cells according to estrogen receptor and HER2 status in early-stage breast cancer" 25 : 5194-5202, 2007
48 Riethdorf S, "Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system" 13 : 920-8, 2007
49 Wang X, "Detection of circulating tumor cells in human peripheral blood using surfaceenhanced raman scattering nanoparticles" 71 : 1526-1532, 2011
50 Mostert B, "Detection of circulating tumor cells in breast cancer may improve through enrichment with anti-CD146" 127 : 33-41, 2011
51 Ring AE, "Detection of circulating epithelial cells in the blood of patients with breast cancer. Comparison of three techniques" 92 : 906-912, 2005
52 Ntoulia M, "Detection of Mammaglobin A-mRNA-positive circulating tumor cells in peripheral blood of patients with operable breast cancer with nested RT-PCR" 39 : 879-887, 2006
53 Königsberg R, "Detection of EpCAM positive and negative circulating tumor cells in metastatic breast cancer patients" 50 : 700-710, 2011
54 Riethdorf S, "Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial" 16 : 2634-2645, 2010
55 Xenidis N, "Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer" 27 : 2177-2184, 2009
56 Mego M, "Cristofanilli M. Molecular mechanisms of metastasis in breast cancerclinical applications" 7 : 693-701, 2010
57 Balic M, "Comparison of two methods for enumerating circulating tumor cells in carcinoma patients" 68 : 25-30, 2005
58 Van der Auwera I, "Circulating tumour cell detection: a direct comparison between the CellSearch System, the AdnaTest and CK-19/mammaglobin RT-PCR in patients with metastatic breast cancer" 102 : 276-284, 2010
59 Cristofanilli M, "Circulating tumor cells, disease progression, and survival in metastatic breast cancer" 351 : 781-791, 2004
60 Theodoropoulos PA, "Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer" 288 : 99-106, 2010
61 Meng S, "Circulating tumor cells in patients with breast cancer dormancy" 10 : 8152-8162, 2004
62 Kasimir-Bauer S, "Circulating tumor cells as markers for cancer risk assessment and treatment monitoring" 13 : 209-215, 2009
63 Mostert B, "Circulating tumor cells (CTCs): detection methodsand their clinical relevance in breast cancer" 35 : 463-474, 2009
64 Apostolaki S, "Circulating HER2 mRNA-positive cells in the peripheral blood of patients with stage I and II breast cancer after the administration of adjuvant chemotherapy: evaluation of their clinical relevance" 18 : 851-858, 2007
65 Munzone E, "Changes of HER2 status in circulating tumor cells compared with the primary tumor during treatment for advanced breast cancer" 10 : 392-397, 2010
66 Kaiser J., "Cancer’s circulation problem" 327 : 1072-1074, 2010
67 Pantel K, "Cancer micrometastases" 6 : 339-351, 2009
68 Obermayr E, "Assessment of a six gene panel for the molecular detection of circulating tumor cells in the blood of female cancer patients" 10 : 666-, 2010
69 Sieuwerts AM, "Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells" 101 : 61-66, 2009
70 Khleif SN, "AACR-FDA-NCI Cancer Biomarkers Collaborative. AACR-FDA-NCI Cancer Biomarkers Collaborative consensus report: advancing the use of biomarkers in cancer drug development" 16 : 3299-3318, 2010
71 Braun S, "A pooled analysis of bone marrow micrometastasis in breast cancer" 353 : 793-802, 2005
72 Stathopoulou A, "A highly specific real-time RT-PCR method for the quantitative determination of CK-19 mRNA positive cells in peripheral blood of patients with operable breast cancer" 119 : 1654-1659, 2006
73 Fehm T, "A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation" 107 : 885-892, 2006
74 Ashworth TR, "A case of cancer in which cells similar to those in the tumours were seen in the blood after death" 14 : 146-147, 1869
75 Zheng S, "3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood" 13 : 203-213, 2011