Inhibition of matrix metalloproteinase-1 and type-I procollagen expression by phenolic compounds isolated from the leaves of Quercus mongolica in ultraviolet-irradiated human fibroblast cells

다국어 초록 (Multilingual Abstract)

The aim of this study was to investigate theeffect of Quercus mongolica (QM) which induce antiphotoagingprocess of skin in vitro. Bioassay-guided isolationof 80 % Me2CO extract of the leaves of QM led tothe isolation and identification of six known phenoliccompounds: pedunculagin (1), (-)-epigallocatechin (2),(?)-catechin (3), quercetin 3-O-(600-O-galloyl)-b-D-glucopyranoside(4), kaempferol-3-O-b-D-glucopyranoside-7-Oa-L-rhamnopyranoside (5) and kaempferol 3-O-(600-galloyl)-b-D-glucopyranoside (6). The effects of compounds1–6 on expression of matrix metalloproteinase-1 (MMP-1)and type-I procollagen were further evaluated. Amongthem, compound 1 showed potent inhibitory effect onMMP-1 and the increased type-I procollagen synthesis inultraviolet B-induced human fibroblast. These results suggestthat pedunculagin, an ellagitannin, is a potential candidatefor the prevention and treatment of skin aging.

참고문헌 (Reference)

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