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    Lin28 is Required for Single Niche Development in the Drosophila Male Gonad

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    https://www.riss.kr/link?id=A108907931

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    A stem cell niche provides an environment that governs stem cell maintenance and division. Thus, the development of a proper niche is of prime importance to stem cell behaviors. Mechanisms of niche development are beginning to be revealed in the Drosophila male gonad. Niche cells are initially dispersed throughout the gonad, then assemble at its apical tip through the anterior migration of posteriorly located niche cells. The molecular mechanisms of this migration and assembly are still poorly understood. Here we show evidence suggesting that Lin28, an RNA-binding protein and regulator of let7 genesis, might be an intrinsic factor for the anterior migration of niche cells. We found that a dispersed, ectopic niche, a phenotype observed with anterior migration defects, occurs in lin28 mutant gonads. This phenotype is rescued by expression of lin28 in the niche cells. These findings suggest that Lin28 might be required for the anterior migration of niche cells.
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    A stem cell niche provides an environment that governs stem cell maintenance and division. Thus, the development of a proper niche is of prime importance to stem cell behaviors. Mechanisms of niche development are beginning to be revealed in the Droso...

    A stem cell niche provides an environment that governs stem cell maintenance and division. Thus, the development of a proper niche is of prime importance to stem cell behaviors. Mechanisms of niche development are beginning to be revealed in the Drosophila male gonad. Niche cells are initially dispersed throughout the gonad, then assemble at its apical tip through the anterior migration of posteriorly located niche cells. The molecular mechanisms of this migration and assembly are still poorly understood. Here we show evidence suggesting that Lin28, an RNA-binding protein and regulator of let7 genesis, might be an intrinsic factor for the anterior migration of niche cells. We found that a dispersed, ectopic niche, a phenotype observed with anterior migration defects, occurs in lin28 mutant gonads. This phenotype is rescued by expression of lin28 in the niche cells. These findings suggest that Lin28 might be required for the anterior migration of niche cells.

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    참고문헌 (Reference)

    1 Anllo L, "Visceral mesoderm signaling regulates assembly position and function of the Drosophila testis niche" 57 : 1009-1023.E5, 2022

    2 Li MA, "The large Maf factor traffic jam controls gonad morphogenesis in Drosophila" 5 : 994-1000, 2003

    3 Gönczy P, "The germ line regulates somatic cyst cell proliferation and fate during Drosophila spermatogenesis" 122 : 2437-2447, 1996

    4 Okegbe TC, "The endoderm specifies the mesodermal niche for the germline in Drosophila via Delta-Notch signaling" 138 : 1259-1267, 2011

    5 Zoller R, "The Drosophila cyst stem cell lineage: Partners behind the scenes?" 2 : 145-157, 2012

    6 Brand AH, "Targeted gene expression as a means of altering cell fates and generating dominant phenotypes" 118 : 401-415, 1993

    7 Morrison SJ, "Stem cells and niches: Mechanisms that promote stem cell maintenance throughout life" 132 : 598-611, 2008

    8 Kiger AA, "Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue" 294 : 2542-2545, 2001

    9 Boyle M, "Specification, migration and assembly of the somatic cells of the Drosophila gonad" 121 : 1815-1825, 1995

    10 Fidler A, "Sonication-facilitated immunofluorescence staining of late-stage embryonic and larval Drosophila tissues in situ" e51528-, 2014

    1 Anllo L, "Visceral mesoderm signaling regulates assembly position and function of the Drosophila testis niche" 57 : 1009-1023.E5, 2022

    2 Li MA, "The large Maf factor traffic jam controls gonad morphogenesis in Drosophila" 5 : 994-1000, 2003

    3 Gönczy P, "The germ line regulates somatic cyst cell proliferation and fate during Drosophila spermatogenesis" 122 : 2437-2447, 1996

    4 Okegbe TC, "The endoderm specifies the mesodermal niche for the germline in Drosophila via Delta-Notch signaling" 138 : 1259-1267, 2011

    5 Zoller R, "The Drosophila cyst stem cell lineage: Partners behind the scenes?" 2 : 145-157, 2012

    6 Brand AH, "Targeted gene expression as a means of altering cell fates and generating dominant phenotypes" 118 : 401-415, 1993

    7 Morrison SJ, "Stem cells and niches: Mechanisms that promote stem cell maintenance throughout life" 132 : 598-611, 2008

    8 Kiger AA, "Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue" 294 : 2542-2545, 2001

    9 Boyle M, "Specification, migration and assembly of the somatic cells of the Drosophila gonad" 121 : 1815-1825, 1995

    10 Fidler A, "Sonication-facilitated immunofluorescence staining of late-stage embryonic and larval Drosophila tissues in situ" e51528-, 2014

    11 Eslahi M, "Signaling pathways in Drosophila gonadal stem cells" 19 : 154-165, 2024

    12 Fairchild MJ, "Occluding junctions maintain stem cell niche homeostasis in the fly testes" 26 : 2492-2499, 2016

    13 Zamfirescu AM, "Notch signaling sculpts the stem cell niche" 10 : 1027222-, 2022

    14 Kitadate Y, "Notch and Egfr signaling act antagonistically to regulate germline stem cell niche formation in Drosophila male embryonic gonads" 107 : 14241-14246, 2010

    15 DeFalco T, "Nonautonomous sex determination controls sexually dimorphic development of the Drosophila gonad" 14 : 275-286, 2008

    16 Voog J, "Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis" 454 : 1132-1136, 2008

    17 Anllo L, "Live imaging reveals hub cell assembly and compaction dynamics during morphogenesis of the Drosophila testis niche" 446 : 102-118, 2019

    18 Dinardo S, "Lines and bowl affect the specification of cyst stem cells and niche cells in the Drosophila testis" 138 : 1687-1696, 2011

    19 Sreejith P, "Lin28 is a critical factor in the function and aging of Drosophila testis stem cell niche" 11 : 855-873, 2019

    20 Van To ; Hyun Ju Kim ; 장위정 ; Perinthottathil Sreejith ; 김창수, "Lin28 and Imp are Required for Stability of Bowl Transcripts in Hub Cells of the Drosophila Testis" 한국발생생물학회 25 (25): 313-319, 2021

    21 Krsnik D, "LIN28 family in testis: Control of cell renewal, maturation, fertility and aging" 23 : 7245-, 2022

    22 Sinden D, "Jak-STAT regulation of cyst stem cell development in the Drosophila testis" 372 : 5-16, 2012

    23 Sreejith P, "Imp interacts with Lin28 to regulate adult stem cell proliferation in the Drosophila intestine" 18 : e1010385-, 2022

    24 Greenspan LJ, "Genetics of gonadal stem cell renewal" 31 : 291-315, 2015

    25 Voog J, "Escargot restricts niche cell to stem cell conversion in the Drosophila testis" 7 : 722-734, 2014

    26 Sênos Demarco R, "Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila" 39 : 110679-, 2022

    27 Le Bras S, "Development of the male germline stem cell niche in Drosophila" 294 : 92-103, 2006

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