Do we need colonoscopy verification in patients with fundic gland polyp?

다국어 초록 (Multilingual Abstract)

Background/Aims: The aim of this study was to evaluate the prevalence of colorectal neoplasia in subjects with fundic glandpolyps (FGPs) and the relationship between FGPs and colorectal neoplasia in Korea. Methods: We analyzed 128 consecutivepatients with FPGs who underwent colonoscopy between January 2009 and December 2013. For each case, age- (±5 years)and sex-matched controls were identified from among patients with hyperplastic polyps, gastric neoplasms, and healthy controls.
Clinical characteristics were reviewed from medical records, colonoscopic findings, pathologic findings, and computedtomography images. The outcome was evaluated by comparison of advanced colonic neoplasia detection rates. Results: Of the128 patients, seven (5.1%) had colon cancers and seven (5.1%) had advanced adenomas. A case-control study revealed that theodds of detecting a colorectal cancer was 3.8 times greater in patients with FGPs than in the age- and sex-matched healthy controls(odds ratio [OR], 3.80; 95% confidence interval [CI], 1.09–13.24; P =0.04) and 4.1 times greater in patients with FGPs than inhealthy controls over 50 years of age (OR, 4.10; 95% CI, 1.16–14.45; P =0.04). Among patients with FGPs over 50 years old, malesex (OR, 4.83; 95% CI, 1.23–18.94; P =0.02), and age (OR, 9.90; 95% CI, 1.21–81.08; P =0.03) were associated with an increasedprevalence of advanced colorectal neoplasms. Conclusions: The yield of colonoscopy in colorectal cancer patients with FGPswas substantially higher than that in average-risk subjects. Colonoscopy verification is warranted in patients with FGPs, especiallyin those 50 years of age or older.

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