간세포암 환자의 발생원인에 따른 말초혈액의 T 세포 아형과 자연살해세포능의 비교 = Natural Killer cell activity and T cell subsets in peripheral blood of hepatocellular cacinoma accodinq to etiology

다국어 초록 (Multilingual Abstract)

Backgrounds : Many cancer patients, such as Hepatocellular carcinoma(HCC), have a compromised cellular immune system. Several lympocytes subpopulations are involved in immunosurveillance against tumors. We try to evaluate on alteration of peripheral T cell subsets, NK cell and NK cell activity in patients with HCC.
Materials and Method : Our study contain 257 patients with chronic liver disease. Of the 257 patients, 147 patients were chronic hepatitis, 44 patients were liver cirrhosis, 66 patients were Hepatocellular carcinoma. We distributed these patients to 3 groups due to cause, chronic hepatitis B (1st group, n=183), chronic hepatitis C (2nd group, n=52), alcoholic liver disease(3rd group, n=22). This study analysis ratio of CD3+, CD4+ CD8+, CD56+ T cell and NK cell activity.
Results : The percentage of CD3+ and CD8+ cells were significantly decreased in LC and HCC groups. The activity of NK cells was significantly decreased in HCC than hepatitis group in HBV group. But not different in HCV and alcohol groups. NK cell and NK cell activity were significant decreased in HCC of younger patients (below 40 years) than older patients (above 60 years).
Conclusions : Our study showed HCC was altered cellular immune system and decreased activity of NK cells. On the basis of this results, it can be suggested that decreased activity of NK cells according to age may be related to differnce of common age, prognosis and response of immune therapy.