<P>Fumiquinazoline S (<B>1</B>), a new quinazoline-containing alkaloid, and the known fumiquinazolines F (<B>6</B>) and L (<B>7</B>) of the same structural class were isolated from the solid-substrate culture ...
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https://www.riss.kr/link?id=A107637055
2015
-
SCI,SCIE,SCOPUS
학술저널
349-354(6쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>Fumiquinazoline S (<B>1</B>), a new quinazoline-containing alkaloid, and the known fumiquinazolines F (<B>6</B>) and L (<B>7</B>) of the same structural class were isolated from the solid-substrate culture ...
<P>Fumiquinazoline S (<B>1</B>), a new quinazoline-containing alkaloid, and the known fumiquinazolines F (<B>6</B>) and L (<B>7</B>) of the same structural class were isolated from the solid-substrate culture of an <I>Aspergillus</I> sp. fungus collected from marine-submerged wood. In addition, isochaetominines A–C (<B>2</B>–<B>4</B>) and 14-<I>epi</I>-isochaetominine C (<B>5</B>), new alkaloids possessing an unusual amino acid-based tetracyclic core framework related to the fumiquinazolines, were isolated from the same fungal strain. The structures of these compounds were determined by combined spectroscopic methods, and the absolute configurations were assigned by NOESY, ROESY, and advanced Marfey’s analyses along with biogenetic considerations. The new compounds exhibited weak inhibition against Na<SUP>+</SUP>/K<SUP>+</SUP>-ATPase.</P><P><B>Graphic Abstract</B>
<IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2015/jnprdf.2015.78.issue-3/np500683u/production/images/medium/np-2014-00683u_0002.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np500683u'>ACS Electronic Supporting Info</A></P>
Pentacyclic Antibiotics from a Tidal Mud Flat-Derived Actinomycete