Pharmacology and therapeutics : a textbook for students and practitioners of medicine

목차 (Table of Contents)

• CONTENTS
• CHAPIER 1. Introduction = 13
• Definitions = 13
• History = 14
• Relation to Other Medical Sciences = 14
• Mode pf Action of Drugs = 15
• Stimulation, Depression, Irritation = 15
• Distribution and Concentration = 16
• Elective Affinity of Drugs = 17
• Protoplasmic Poisons = 17
• Local, General and Remote Actions = 17
• Pharmacologic Svndroms = 18
• General Theories of Phamacologic Action = 19
• Biological Antagonisms = 19
• Chemical Constitution and Pharmacologic Action = 21
• Conditions Modifying the Effects of Drugs = 22
• Drug idosincracy = 27
• Methods of Admnistration of Drugs = 28
• Chemical Character of Drugs = 33
• The Pharmacopieas and other Official Publications = 36
• Official Preparations = 36
• Biological Assay = 3
• 2. General Anesthesia = 43
• History = 46
• Stages of Atiesthesia = 46
• Action = 48
• On Nervous System = 49
• On Respiration = 40
• On Circulation = 42
• On Heart = 52
• On Blood Vessels = 53
• Other Actions = 53
• Mechanism of Action = 54
• Absorption and Excretion = 55
• Anesthetic Deaths = 56
• Ether = 56
• Chloroform = 58
• Nitrous Oxide = 58
• Action = 59
• Method of Administration = 59
• Ethylene = 60
• Cyclopropane = 61
• Divinyl Ether = 63
• TribromoeThanol = 63
• Trichlorethylene = 64
• Ethyl Chloride = 64
• Acetylene = 65
• Intravenous Anesthesia = 65
• Combined Anestliesia = 66
• Therapeutic Use = 66
• 3. Thee Aliphatic AIcohols = 71
• Ethyl Alcohol = 71
• Action = 71
• Absorption and Excretion = 71
• Alcoliol as a Food = 78
• Metabolism = 79
• Otlier Effects = 79
• Alcoholisim = 80
• Therapeutic Uses = 82
• Methyl Alcoho = 84
• Other Aliphatic Alcohols = 85
• Glycols = 85
• 4. Morpliine and Otlier Opium Alkaloids = 88
• Chemstry = 88
• Morphine = 91
• Action = 91
• Absorption and Excretion = 97
• Toleratice and Addiction = 97
• Poisoning = 98
• Codeine = 100
• Dihydrocodeinone = 100
• Dihydromorphinone = 100
• Heroin（Diamorpliine） = 101
• Metolpon llydroochloride = 102
• Apomorphine = 102
• Papaverine = 103
• Therapeutic Uses = 104
• Minor Naturally Occurring Narcotics = 106
• 5. Analgesics and Antipyretics = 112
• Non Opiate Addicting Analgesics = 113
• Meperidine = 113
• Methadone = 114
• Antipyretic Analgesics = 116
• Acetanilid and Antipyrine Series = 116
• Antirheumatic Analgesics = 124
• Salicylates = 124
• Colchicine = 129
• Cincophen and Its Derivatives = 131
• 6. Hypnotics and Sedatives = 137
• Barbituric Acid Derivatives = 138
• Chemistry = 138
• Action = 139
• Absorption and Excretion = 141
• Habituation and Poisoning = 141
• Therapeutic Uses = 143
• Chloral Hydrate = 144
• Other Chloral Derivatives = 146
• Paraldehyde = 146
• SuIfonmetbanes = 147
• 7. Anticonvulsitnts or Antiepileptics = 151
• The Bromides = 151
• Action = 152
• Symptoms = 152
• Distribution and Exeretion = 153
• Chronic Intoxication = 154
• Therapeutic Use = 155
• Other Bromine Containg Sedatives = 156
• DiPhenylhydantoin （Phenytonium） = 156
• Trimerthadione = 158
• Paramethadione = l58
• Mesantoin = 159
• Mephobarbital = 159
• 8. Convulsants and Analeptics = 161
• Strychnine = 162
• Pentylenetetrazole （Leptazol） = 166
• Nikethamide = 167
• Piclotoxi = 168
• Champhor = 170
• 9. The Xanthines : Caffeine, Thebromine and Theophylline = 173
• Action = 174
• Absorption and Excretion = 178
• Therapeutic Uses = 179
• Coffee and Tea = 180
• Other Diuretics = 181
• 10. Drugs Acting on Autonomic Effecor Cells = 184
• Neurohormonal Mechanism Underlying Autonomic Nervous System Activity = 184
• Chemical Mediators of Autonomic activity = 186
• Mediators of Adrenergic Action = 187
• Classification of Autonomic Drugs = 188
• Autonomic Functions = 189
• Therapeutic Uses = 193
• 11. EpinePhrine and Other Drugs Stimulating Structures Innervated by Adrenergic Nerves = 195
• Epinephrine （Adrenaline） = 195
• Chemstry = 195
• Action = 196
• Toxicology = 203
• Therapeutic Uses = 203
• Norepinephrine （Noradrenaline） = 205
• Ephedine = 207
• Relation Of Chemical Structure to Pharmacologic Activity = 209
• Amphetamine = 210
• Methamphetamine = 212
• Phenylephrine = 212
• Other Aromatic Sympathomimetic Amines = 213
• Aliphatic Amines = 217
• 12. Drugs lnhibiting Structures Inervated by Adrenergic Nerves = 220
• Ergot and Its Alkanoids = 220
• Chemistry = 220
• Toxicology = 223
• Action = 223
• Assay = 228
• Therapeutic Uses = 228
• Dihydrogenated Ergot Alkaloids = 230
• Dioxane Derivatives = 230
• Dibenzychorethylene = 231
• Other Adrenergic Blocking Agents = 233
• 13. Drugs Stimulating Structures Innervated by Cholinergic Nerves = 236
• Acetylcholine = 236
• Action = 237
• Other Choline Derivatives = 238
• Methacholine = 239
• Action = 240
• Therapeutic Uses = 241
• Carbachol = 241
• Bethanechol Chloride = 241
• Furtrethonium iodide = 242
• Muscatine = 243
• Actions = 243
• Mushroom Poisoning = 245
• Pilocarpine = 246
• Action = 246
• Therapeutic Uses = 248
• Arecoline = 248
• Physostigmine = 249
• Sytilptoms = 250
• Action = 250
• Therapeutic Uses = 252
• Neostigmine = 252
• Action = 253
• Therapeutic Uses 25 = 3
• Diisopropyl Fluorophosphate = 254
• 14. Depressants of the Postganglionic Cholinergic Nerves = 258
• The Atropine Series = 258
• Occurrence = 258
• Chemistry = 258
• Action = 260
• Hyoscyamine = 270
• Scopolamine = 270
• Homatropine and Other Artificial Tropeines = 270
• Preparations = 272
• Therapeutic Uses = 272
• Other Synthetic Substitutes for the Belladonna Alkaloids = 276
• 15. Inhibiting Autonomic Ganglia and Skeletal Muscles = 281
• Nicotine = 281
• Symptons = 282
• Actions = 282
• Tobacco = 287
• Curare = 289
• Chemistry = 289
• Action = 290
• Therapeutic Uses = 293
• Other Curariform Agents = 294
• Tetraethylammonuim Salts = 296
• 16. histamine and Antihistaminic Compounds = 300
• Histamine = 300
• Action = 303
• Therapeutic Uses = 303
• R$$hat o$$le in Allergy and Anaphylaxis = 304
• Histamine-Antagonizing Agents = 305
• Chemistry = 308
• Action = 308
• Therapeutic Uses = 310
• 17. Local and Regional Anesthetics = 313
• Local Anesthesia = 313
• Cocaine = 316
• Chemistry = 316
• Action = 317
• Therapeutic Uses = 322
• Synthetic Local Anesthetics = 322
• Slightly Soluble Local Anesthetics = 328
• 18. Drugs Acting Primary on the Cardiovascular System = 331
• The Digitalis Series = 331
• Occurrence = 333
• Chemistry = 333
• Action = 336
• Absorption and Distribution = 345
• Assay = 346
• Therapeutic Cses = 347
• Preparations, Dosage and Methods of Administration = 351
• Digitalis Intoxication = 354
• The Nitrites, Nitrates and Nitrous Esters = 357
• Amyl Nitrite = 357
• Nitroglycerin = 361
• Therapeutic Uses = 362
• Quinidine = 365
• Minor Drugs = 367
• 19. Drugs Acting Primary on the Gastrointestinal Tract = 372
• Simple Bitters = 373
• Demulcents = 373
• Digestants = 375
• Carminatives = 378
• Absorbents = 378
• Antacids = 379
• Cathartics = 382
• Aperients = 385
• Atithracene Purgatives = 388
• Phenolphthalein = 390
• Drastic l'urgitives = 392
• Saline Cathartics = 392
• Anthelmintics = 400
• 20. Chemotheraphy = 410
• History = 410
• Experimental Chemothereapy = 412
• Chemotherapeutic Activity = 412
• Pharmacology = 413
• Drug Resistance = 414
• Mechanism of Action = 414
• Chemotherapeutic Agents = 415
• Trypanosomiasis = 415
• The Diamldine = 416
• Other Organic Chemotherapeutic Agents = 418
• Therapeutic Uses = 419
• 21. The Sulfonamides and Related Compounds = 422
• History = 422
• Chemostry = 424
• Pharmacology = 424
• Toxicology = 425
• Principal Derivatives = 428
• Action = 434
• Therapeutic Uses = 436
• 22. The Antibiotics = 442
• Penicillin = 442
• Streptomicin and Dihydrostreptomycin = 455
• Aureomycin = 461
• Chloramphenicol （Chloromycetin） = 463
• Antibiotics Derived front Bacteria = 465
• Other Antibiotics = 466
• 23. Quinine and Other Antimalarials = 471
• Malaria = 471
• Quinine = 473
• Chemistry = 473
• Action = 474
• Toxicotogy = 477
• Excretion = 478
• Therapcutic Uses = 478
• Quinacrine （Mepacrine） = 480
• Pamaquine （Plasmochin, Plasmoquine） = 482
• Chloroquine = 483
• Pentaquine = 484
• Chloroguanide （Paludrine） = 485
• 24. Emetine and Other Amiebacidal Drugs = 489
• Emetine = 490
• Chemistry = 490
• Action = 490
• Toxicology = 491
• Therapeutic Use = 491
• Other Arsenical Amebacides = 493
• Carbarsone = 492
• Hydroxyquinoline Deiivatives = 194
• 25 .Local Anti-infectives and Other Drugs Characterized Chiefly by Their Local Action = 498
• Antiseptics and Disinfectants = 498
• Surgical Antiseptics and Disinfectants = 502
• Antiseptics Used Chiefly in Skin Diseases = 522
• Genito-Urinary Antiseptics = 525
• Disinfectants for Rooms, Furniture, etc = 528
• Insecticides and Rodenticides = 531
• Emollients and Protectives = 533
• Astringents = 534
• Volatile Oil Series = 535
• Skin Irritants and Counter-Irritation = 536
• Toxic Skin Irritants = 539
• 26. The Hormones and Drugs Acting on the Endocrine Organs = 541
• Anterior Lobe of Pituitary = 542
• Posterior Lobe of Pituitary = 545
• The Thyroid Gland = 553
• Antithyroidal Drugs = 560
• The Parathyroids = 563
• The Adrenal Cortex = 566
• lnsuline = 571
• The Sex Hormones = 577
• The Gonadotropins = 77
• The Female Sex Hormones = 578
• Estrogens = 578
• Progestetional Compounds = 585
• Male Sex Hormones = S86
• 27. The Vitamins = 590
• Vitamin A = 592
• The Vitamins B complex = 596
• Thamine = S97
• Riboflavin = 600
• Niacin and nicotinamide = 601
• Pyridoxine = 604
• Pantrothenic Acid = 604
• Biotin = 605
• Para-aminobenzoic Acid = 606
• Choline, Inositol and Other Lipotropic Agents = 606
• Vitamin C = 607
• Vitamin P and Rutin = 610
• Vitamin D = 611
• Vitamin E = 614
• 28. Drugs Acting on the Blood and Hematopoietic = 617
• Blood and Its Fractions = 617
• Antianemic Agents = 619
• Iron = 619
• Liver and Liver Preparations = 623
• Stomach Preparations = 626
• Vitamin $$B_{12}$$ = 627
• Folic Acid = 629
• Folic Acid Derivatives = 631
• Coagulants and Anticoagulants = 632
• Local Coagulants = 633
• Vitamin K = 634
• Heparin = 636
• Biscumarol = 638
• Drugs Used in Polycythemia and Leukemia = 640
• Radioactive Phosphorus = 640
• Nitrogen Mustard = 641
• Urethane = 642
• 29. Water and Other Non-Metallic Compounds = 644
• Water = 646
• Sodium Salts = 649
• Sodium Chloride = 650
• Potassium Salts = 653
• Lithium Cesium and Rubidium Salts = 655
• Ammonium Salts = 656
• Caustic Alkalis = 658
• Saline Diuretics = 661
• Salts of Alkaline Earths = 662
• Calcium = 662
• Magnesium = 665
• Barium = 667
• Strontium = 668
• BalaDced Salt Solutions = 669
• Acids = 669
• Anions = 672
• Phosphorus and Phosphates = 672
• Acetates, Lactates and Citrates = 674
• Oxalates = 675
• Fluorides = 676
• Sulfides = 677
• Iodine and Iodides = 678
• Gases = 684
• Oxygen = 684
• Carbon Dioxide = 686
• Carbon Monoxide = 687
• Helium = 688
• 30. The Metalloids ; Arsenic, Antimony and Bismuth = 690
• Inorganic Preprations of Arsenic = 690
• Treatment of Arsenic Poisoning = 695
• Organic Arsenic Prelarations = 695
• Arsenicals Used in Syphilotherapy = 698
• Mechanism of Action = 700
• Therapeutic Use = 700
• Antimony Compounds = 701
• Toxicology = 701
• Trivalent Antimony Compounds = 702
• Pentavalent Antimony Compounds = 703
• Therapeutic Uses = 704
• Bismuth Compounds = 705
• Symptoms = 70i
• Toxicology = 705
• Organic Bismuth Preparations = 708
• Therapeutic Uses = 708
• 31. The Fleavy Metals = 711
• General Action = 712
• Dimercaptrol = 713
• Iron = 714
• Cooper = 717
• Zinc = 718
• Alumnum = 720
• Lead = 721
• Silver = 727
• Mercury = 728
• Mercurial Diuretics = 734
• Gold = 736
• Minor Metals = 737
• Radioactive Elements and Isotopes = 741
• 32. Vaccines, Sera and Miscellaneous Biologicals = 744
• Vaccines, Toxins and Toxoids = 744
• Antitoxic Sera, Immune Sera and Antitoxins = 747
• Protein flydrolysates = 749
• Diagnostic Agents = 749
• Appendix A - Prescription Writing = 753
• Appendix B - Classification of Drugs According to their Therapetitic Uses = 759
• Index = 766