불화나트륨(NaF), 세틸피리디니움 클로라이드(CPC) 및 우루소데옥시콜린산(UDCA)을 함유한 구강양치액의 치면세균막과 치은염에 미치는 효과에 관한 임상적 실험연구 = Clinical Study of Mouth Rinse Containing Sodium Fluoride, Cetylpyridinium Chloride and Ursodeoxycholic Acid on Dental Plaque and Gingivitis

다국어 초록 (Multilingual Abstract)

The purposes of this clinical study were to determine and compare the antiplaque and antigingivitis effectiveness of an experimental mouthrinse containing sodium fluoride(NaF), cetylpyridinium chloride(CPC) and ursodeoxycholic acid(UDCA) by following the American Dental Association(ADA) guidelines for acceptance of chemotherapeutic products for the control of supragingival dental plaque and gingivities. A mouth rinse containing 0.02% NaF and a commercial over-the-counter mouthrinse, Listerine. which was accepted by the ADA, were used as a negative and positive control group respectively in this study. the active ingredients of the two experimental mouthrinses were either the two component of 0.02% NaF and 0.05% CPC or three component of 0.02% NaF, 0.05% CPC and 0.005% UDCA.
A total of 220 human subjects, between 18 and 30 years of age, were stratified into four balanced groups of 55 each according to age and baseline patient hygiene performance (PHP) index and Lo¨e-Silness Gingival Index(GI) scores. Each group was randomly assigned to the use of one of test mouthrinses. They were instructed to rinse twice (in the morning and immediately prior to bed time) daily for 60 seconds with 10 to 15ml of their assigned. Other oral hygiene practice were not allowed for four weeks of study period. the PHP and GI indices were determined weekly intervals. After 4 weeks' use of test mouthrinses, the indices obtained from 117 subjects who completed the study were statistically analysed and compared the differences among test rinses.
After four weeks, the use of rinse containing two component of NaF and CPC provided a significant reduction of PHP index by 48% (P＜0.01) and GI index by 26% (P＜0.01). the use of three component of NaF, CPC and UDCA significantly reduced PHP index and GI by 63 and 29% respectively (P＜0.05). However, no statistical differences were indicated between the positive control (Listerine) and either the two component or three component mouthrinses. No statistical differences were also indicated between two component (NaF and CPC) and three component (NaF, CPC and UDCA) mouthrinses. However, there were numerically lower indices in three component rinse as compare to two component rinse after 4 weeks of experimental period.
These results indicate that twice daily use of either the CPC rinse or CPC and UDCA rinse in the presence of fluoride significantly reduces PHP and GI induces as compared to negative NaF control rinse.