Dimethylnitrosamine이 흰쥐의 내분비에 미치는 영향 = Effects of Dimethylnitrosamine on Biochemical Endocrine of Rat

국문 초록 (Abstract)

1. 배란기 전에 dimethylnitrosamine (DMN)을 rat에 투여하면 progesterone과 estradiol-$17{\beta}$의 분비를 억제시키나 DMN처리 농도에 따른 hormone 분비양에는 큰 차이가 없었다. 2. 임신한 rat에 DMN을 투여하면 배란기와 착상초기 까지는 estradiol-$17{\beta}$의 분비를 억제시키고 착상기가 진행됨에 따라 분비를 촉진시킨다. 3. 또한 임신한 rat에 DMN을 투여했을 때 progesterone 분비에 미치는 영향은 estradiol-$17{\beta}$의 경우와 유사한 경향을 나타내었다.

다국어 초록 (Multilingual Abstract)

1. When dimethylnitrosamine (DMN) was injected to Wistar female rat before the ovulation, the sercetion of progesterone and estradiol-$17{\beta}$ was substantially suppressed. However, the different levels of these hormone secretion according to the DMN concentration was not significant. 2. In the case of the pregnant rats, DMN inhibited the secretion of estradiol-$17{\beta}$ at the stage of ovulation and early implantation. In contrast with the above facts, the secretion of this hormone was enhanced during the progressive implantation. 3. A similar behavior with the one of estradiol-$17{\beta}$ was also observed in the secretion of progesterone for the case of the pregnant rats treated with DMN.