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https://www.riss.kr/link?id=A3367140
1985
-
500
SCOPUS,KCI등재,ESCI
학술저널
65-75(11쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
In order to test the hypothesis that periportal(acinar zone 1) and pericentral(acinar zone 3) necrosis can be differentiated by measurement of serum fructose-l, 6-diphosphatase (FDP) which has been reported to be predominanely distributed in the perip...
In order to test the hypothesis that periportal(acinar zone 1) and pericentral(acinar zone 3) necrosis can be differentiated by measurement of serum fructose-l, 6-diphosphatase (FDP) which has been reported to be predominanely distributed in the periportal zone of the acinus, the enzyme was assayed in serum during periportal necrosis induced by allyl alcohol(0.62m mole/kg, dissolved in 0.9% NaCl Itraperitoreally) and during pericentral necrosis by bromobenzene(3.80m mole/kg, dissolved in corn oil, intraperitoneally), and the activities were compared in two conditions. Serum FDP activities in normal saline control, allyl alcohol-treated normal histologic finding, minimal, moderate and severe periportal necrosis groups were 0.005+-0.018, 0.048+-0.018,0.090+-0.009,0.113+-0.029 and 0.140+-0.010 unit/ml, respectively. The levels in moderate and severe periportal recros group were significantly(p<p.01) elevated in comparison with those of normal control. Serum FDP activities in normal corn oil control, bromobenzene treated normal histologic finding, minimal, moderate and severe pericentral necrosis groups were 0.056+-0.014, 0.048+-0.014. 0.059+-0.021, 0.078+-0.021 and 0.124+-0.12 unit/ml, respectively, and it showed that the levels in minimal and moderate necrosis groups were nearly the same as those in normal control, and only those in group of severe necrosis showed significant (p<0.0l) elevation. The ALT and FDP activities between two groups have significantly correlated (r=0.665, r = 0.724), but the regression equation that is y=0.0085 x+0.069 or y=0.01 x +0.04 respectively, was significantly different. These results indicated that at least experimental necrosis of the periportal and perice- ntra! Zones in the rats can be differentiated by measurement of serum FDP. And it was suggested that simultaneous measurements of either serum beta-hydroxybutyric dehydrogenase or pyruvate kinase which was reported to be predominantly distr ibuted at the pericentral zone would help to differentiate more precisely.
식도정맥류의 (食道靜脈瘤) 내시경 (內視鏡) 및 임상적 (臨床的) 고찰
Superoxide Dismutase 가 Aspirin 에 의한 흰쥐 위점막 병변에 미치는 영향
칼슘 길항제가 흰쥐의 위산 분비 및 혈청 Gastrin 에 미치는 영향