Environmental endotoxin exposure influences the severity of asthma in house dust mite allergen sensitized subjects. In the domestic environment high levels of endotoxin are present in reservoir floor and bedding dust. Clothing is known to be an import...
Environmental endotoxin exposure influences the severity of asthma in house dust mite allergen sensitized subjects. In the domestic environment high levels of endotoxin are present in reservoir floor and bedding dust. Clothing is known to be an important source of allergen exposure, but it is not yet known if this is so for endotoxin. We determined endotoxin levels from winter upper garment clothing with the Limulus amebocyte lysate assay. The geometric mean (95% CI) endotoxin level from 34 colothing items was 17.540 EU/gm. More recently washed clothing (<2 weeks) contained lower endotoxin levels than less frequently washed clothing (>2 weeks), geometric means (95% CI): 9.772 (3,500~28,440) and 20,420 (16,670~24,950) EU/gm dust restectively (p=.017). These levels are high and similar to endotoxin levels from carpets and bedding. This results suggest that clothing is potentially a major source of endotoxin exposure.