실험적으로 유도된 이독성 난청에서의 Ginkgo Extract의 효과 = The Effects of Ginkgo Extract on the Experimentally Induced Ototoxicity in Guinea Pigs

국문 초록 (Abstract)

이독성 난청에서의 Ginkgo extract의 효과를 보고자 기닉픽 22마리를 대상으로 이음향방사를 측정하여 난청군과 치료군을 비교 검토한 바 성적을 요약하면 다음과 같다.
난청군에서의 DP-OAE는 대군조에 비해 전 주파수에서 감소 내지 소실을 보였으며4KHz 에서만 선택적으로 큰 감소를 나타낸것도 있었다. Ginkgo estract로 예방 치료한 군에서는 난청군에 비해 DP-OAE가 현저하게 출현 하였으며 정상 DP-OAE소견을 나타낸 것도 있었다. 난청치료군에서도 난청군에 비해 전체적으로 DP-OAE 가높게 출현되고 있었다. 이상의 소견으로 보아 Ginkgo estract가 이독성 난청과 감각신경성 난청에서의 예방 및 치료 효과의 가능성을 제시해 준다고 생각되는 바이다.

다국어 초록 (Multilingual Abstract)

This study was designed to investigate the effect of Ginkgo biloba extract on the kanamycin induced ototxicity in inner ears 22 guinea pigs. The animals were divied into 4 groups.
In ototoxic group, kanamycin was injected 400mg/kg per day for 7 to 10 days. In preventive treated group, kanamycin with same dose and Ginkgo biloba extract(50mg/kg)were simultaneously injected daily for same duration. In post treated toup, Ginkgo extract was treated for 15 days in kanamycin injected group. The Preyer's reflex and DP-OAE (distortion product otoacoustic emissions) were used for the monitoring of hearing changes. In the ototoxic group, the amplitude of DP-OAE was marked decreased or disappeared in all test frequencies or 4KHz only. The Preyer's reflex was disappeared in all ototoxic group. In the preventive treated group with Ginkgo extract, normal DP-OAE or slightly decreased DP-OAE in 4 KHz was noticed. This finding was seemed to be similar to the post-treated group. From the above results, Ginkgo extract is suggested to have beneficial effects for the management of ototoxicity and sensorineural hearing loss.