Cortisone이 角膜 上皮細胞 再生에 미치는 影響 = EFFECTS OF CORTISONE ON THE REGENERATION OF CORNEAL EPITHELIUM

다국어 초록 (Multilingual Abstract)

The wide spread use of cortisone in ophthalmology promptly led to questions about the possible deleterious effects of this agent on the healing of wounds in the eye. The authors think that we have already reached the stage of conclusion about the influences of cortisone on the penetrating wounds, corneal vascularization and fibroblastic repair. Nevertheless, some conflicts are yet present about the influence on the regeneration of corneal epithelium.
We present the results of our studies on the effects of cortisone on one standard experimental abrasions made in normal rabbits corneas. Cortisone was given by local instillation and subconjunctival injection, and examined the results by histologic study and by fluorescein staining method on the unhealed area.
1. Cortisone administered as drops in the conjunctival sac are innocous on the regeneration of corneal eqithelium in concertrations up to and including 25㎎/㏄.
2. In subconjunctival injection, the cortisone groups showed white subconjunctival areas thought to be cortisone deposits and severe congestion and markedly dilatated vessels. The control groups, showed no white subconjunctival deposits and generally the local reactions were slight. Some delayed wound healing was found in the non-diluted group (25㎎/㏄.). However, in the 1 : 4 diluted solution group, there were no delayed wound healings.
3. When cortisone is used subconjunctivally, one must be careful on the doses, times, and intervals.
(Read before the 7th annual session of Korean Academy of ophthalmology. June, 1955, Soul.)