재조합 단백질을 이용한 HPV 6b와 16감염의 혈청학적 진단

다국어 초록 (Multilingual Abstract)

Recently the investigation of the immune responses to Human papillomavirus(HPV) infection has been employed to identify serological markers that are associated with anogenital malignancies and/or disease progression. We investigated serological responses in sera from Korean women with or without a history of cervical carcinoma. We used bacterially derived trpE fusion proteins as antigens for Western blot assays. Among women with cancer, 16/32(50%) and 20/32(63%) were positive for antibodies to at leat one of gene products of HPV 16 in the sera of cervical cancer patients were 47% (15/32; E4), 19%(6/32; E6), 38%(12/32; E7), 22% (7/32; Ll), and 6%(2/32; L2), respectively, while none for E4, E6 and L2, 2/20 for E7(10%), and 1/20 for Ll(5%) among the cancer-free individuals. The detection rate of antibodies to the HPV 16 appeared to be higher in the cervical carcinomas, implying the correlation between HPV 16 and cervical carcinoma, although the stastical significance of this interpretation should wait for the analysis of more cases.