Managing Thyroid Microcarcinomas

다국어 초록 (Multilingual Abstract)

Papillary thyroid microcarcinomas (PTMCs) are the most common form of classic papillary thyroid carcinoma (PTC). PTMCs are typically discovered by fine-needle-aspiration biopsy (FNAB), usually with sensitive imaging studies, or are found during thyroid surgery in a patient without a previously known history of thyroid carcinoma. However, the definition of PTMC has not always been universally accepted,thus creating controversy concerning the diagnosis and treatment of PTMC. The aim of this review is to summarize the clinical features of PTMC and identify the widely differing opinions concerning the diagnosis and management of these small ubiquitous thyroid tumors.

참고문헌 (Reference)

1 Page C, "‘Aggressive papillary’ thyroid microcarcinoma" 266 : 1959-1963, 2009

2 DeLellis RA, "World Health Organization Classification of Tumours. Pathology and genetics of tumours of endocrine organs" IARC Press 54-55, 2004

3 Nam-Goong IS, "Ultrasonography-guided fine-needle aspiration of thyroid incidentaloma: correlation with pathological findings" 60 : 21-28, 2004

4 Yeo PP, "Thyrotoxicosis and thyroid cancer" 12 : 589-593, 1982

5 Roti E, "Thyroid papillary microcarcinoma: a descriptive and meta-analysis study" 159 : 659-673, 2008

6 Barbaro D, "Thyroid papillary cancers: microcarcinoma and carcinoma, incidental cancers and non-incidental cancers - are they different diseases?" 63 : 577-581, 2005

7 Arem R, "Thyroid microcarcinoma: prevalence, prognosis, and management" 5 : 148-156, 1999

8 Tan GH, "Thyroid incidentalomas: management approaches to nonpalpable nodules discovered incidentally on thyroid imaging" 126 : 226-231, 1997

9 Topliss D., "Thyroid incidentaloma: the ignorant in pursuit of the impalpable" 60 : 18-20, 2004

10 Fukunaga FH, "Thyroid carcinoma in the Japanese in Hawaii" 92 : 6-13, 1971

11 Silliphant WM, "Thyroid carcinoma and death. A clinicopathological study of 193 autopsies" 17 : 513-525, 1964

12 Steliarova-Foucher E, "Thyroid cancer incidence and survival among European children and adolescents (1978-1997): report from the Automated Childhood Cancer Information System project" 42 : 2150-2169, 2006

13 Mitchell J, "The thyroid incidentaloma: an increasingly frequent consequence of radiologic imaging" 26 : 37-46, 2005

14 Zhai G, "The role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography whole body imaging in the evaluation of focal thyroid incidentaloma" 33 : 151-155, 2010

15 Vanderlaan WP, "The occurrence of carcinoma of the thyroid gland in autopsy material" 237 : 221-, 1947

16 Hughes DT, "The most commonly occurring papillary thyroid cancer in the United States is now a microcarcinoma in a patient older than 45 years" 21 : 231-236, 2011

17 Giannini R, "The heterogeneous distribution of BRAF mutation supports the independent clonal origin of distinct tumor foci in multifocal papillary thyroid carcinoma" 92 : 3511-3516, 2007

18 Greene FL, "The TNM system: our language for cancer care" 80 : 119-120, 2002

19 Shie P, "Systematic review: prevalence of malignant incidental thyroid nodules identified on fluorine-18 fluorodeoxyglucose positron emission tomography" 30 : 742-748, 2009

20 Ries LAG, "SEER Cancer Statistics Review, 1997-2003"

21 Cohen MS, "Risk of malignancy in thyroid incidentalomas identified by fluorodeoxyglucose-positron emission tomography" 130 : 941-946, 2001

22 Papini E, "Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features" 87 : 1941-1946, 2002

23 Enewold L, "Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005" 18 : 784-791, 2009

24 Hogan AR, "Pediatric thyroid carcinoma: incidence and outcomes in 1753 patients" 156 : 167-172, 2009

25 Falvo L, "Papillary microcarcinoma of the thyroid gland: analysis of prognostic factors including histological subtype" 28-32, 2003

26 Park YJ, "Papillary microcarcinoma in comparison with larger papillary thyroid carcinoma in BRAF(V600E) mutation, clinicopathological features, and immunohistochemical findings" 32 : 38-45, 2010

27 Schönberger J, "Papillary microcarcinoma and papillary cancer of the thyroid

28 Noguchi S, "Papillary microcarcinoma" 32 : 747-753, 2008

29 Appetecchia M, "Outcome after treatment of papillary thyroid microcarcinoma" 21 : 159-164, 2002

30 Komorowski RA, "Occult thyroid pathology in the young adult: an autopsy study of 138 patients without clinical thyroid disease" 19 : 689-696, 1988

31 Furmanchuk AW, "Occult thyroid carcinomas in the region of Minsk, Belarus. An autopsy study of 215 patients" 23 : 319-325, 1993

32 Sampson RJ, "Occult thyroid carcinoma in Olmsted County, Minnesota: prevalence at autopsy compared with that in Hiroshima and Nagasaki, Japan" 34 : 2072-2076, 1974

33 Bondeson L, "Occult thyroid carcinoma at autopsy in Malmö, Sweden" 47 : 319-323, 1981

34 Solares CA, "Occult papillary thyroid carcinoma in postmortem species: prevalence at autopsy" 26 : 87-90, 2005

35 Otino A, "Occult papillary thyroid carcinoma at autopsy in La Plata, Argentina" 64 : 547-551, 1989

36 Lang W, "Occult carcinomas of the thyroid. Evaluation of 1,020 sequential autopsies" 90 : 72-76, 1988

37 Autelitano F, "Occult carcinoma of the thyroid gland: an epidemiological study of autopsy material" 61 : 141-146, 1990

38 Pelizzo MR, "Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): a mono-institutional 12-year experience" 25 : 547-552, 2004

39 김경희, "Mutations of the BRAF Gene in Papillary Thyroid Carcinoma in a Korean Population" 연세대학교의과대학 45 (45): 818-821, 2004

40 Baudin E, "Microcarcinoma of the thyroid gland: the Gustave-Roussy Institute experience" 83 : 553-559, 1998

41 Baloch ZW, "Microcarcinoma of the thyroid" 13 : 69-75, 2006

42 Antonaci A, "Microcarcinoma and incidental carcinoma of the thyroid in a clinical series: clinical behaviour and surgical management" 157 : 225-229, 2006

43 Silver RJ, "Management of thyroid incidentalomas" 84 : 907-919, 2004

44 Wada N, "Lymph node metastasis from 259 papillary thyroid microcarcinomas: frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection" 237 : 399-407, 2003

45 Tubiana M, "Long-term results and prognostic factors in patients with differentiated thyroid carcinoma" 55 : 794-804, 1985

46 Sobrinho-Simôes MA, "Latent thyroid carcinoma at autopsy: a study from Oporto, Portugal" 43 : 1702-1706, 1979

47 Kilfoy BA, "International patterns and trends in thyroid cancer incidence, 1973-2002" 20 : 525-531, 2009

48 Leenhardt L, "Indications and limits of ultrasound-guided cytology in the management of nonpalpable thyroid nodules" 84 : 24-28, 1999

49 Davies L, "Increasing incidence of thyroid cancer in the United States, 1973-2002" 295 : 2164-2167, 2006

50 Chen AY, "Increasing incidence of differentiated thyroid cancer in the United States, 1988-2005" 115 : 3801-3807, 2009

51 Lin JD, "Increased incidence of papillary thyroid microcarcinoma with decreased tumor size of thyroid cancer" 27 : 510-518, 2010

52 Kent WD, "Increased incidence of differentiated thyroid carcinoma and detection of subclinical disease" 177 : 1357-1361, 2007

53 Pezzolla A, "Incidental carcinoma in thyroid pathology: our experience and review of the literature" 81 : 165-169, 2010

54 Lin JD, "Incidental and nonincidental papillary thyroid microcarcinoma" 15 : 2287-2292, 2008

55 King DL, "Incidence of thyroid carcinoma in fluorodeoxyglucose positron emission tomography-positive thyroid incidentalomas" 137 : 400-404, 2007

56 Durante C, "Identification and optimal postsurgical follow-up of patients with very low-risk papillary thyroid microcarcinomas" 95 : 4882-4888, 2010

57 Yeo PP, "Hyperthyroidism with coexisting thyroid carcinoma: a study of 14 patients" 10 : 323-325, 1981

58 Lin JD, "High recurrent rate of multicentric papillary thyroid carcinoma" 16 : 2609-2616, 2009

59 Pelizzo MR, "High prevalence of occult papillary thyroid carcinoma in a surgical series for benign thyroid disease" 76 : 255-257, 1990

60 Mortensen JD, "Gross and microscopic findings in clinically normal thyroid glands" 15 : 1270-1280, 1955

61 Bilimoria KY, "Extent of surgery affects survival for papillary thyroid cancer" 246 : 375-381, 2007

62 Rossi R, "Differentiated thyroid cancers 11-20 mm in diameter have clinical and histopathologic characteristics suggesting higher aggressiveness than those < or =10 mm" 18 : 309-315, 2008

63 Basolo F, "Correlation between the BRAF V600E mutation and tumor invasiveness in papillary thyroid carcinomas smaller than 20 millimeters: analysis of 1060 cases" 95 : 4197-4205, 2010

64 Lee JH, "Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid - A meta-analysis" 110 : 38-46, 200707

65 Brierre JT Jr, "Clinically unsuspected thyroid disease" 30 : 94-98, 1964

66 Pazaitou-Panayiotou K, "Clinical features and therapeutic implication of papillary thyroid microcarcinoma" 17 : 1085-1092, 2007

67 Pellegriti G, "Clinical behavior and outcome of papillary thyroid cancers smaller than 1.5 cm in diameter: study of 299 cases" 89 : 3713-3720, 2004

68 Alston RD, "Changes in cancer incidence in teenagers and young adults (ages 13 to 24 years) in England 1979-2003" 113 : 2807-2815, 2008

69 Belfiore A, "Cancer risk in patients with cold thyroid nodules: relevance of iodine intake, sex, age, and multinodularity" 93 : 363-369, 1992

70 American Cancer Society, "Cancer Facts and Figures 2009"

71 Nikiforova MN, "BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas" 88 : 5399-5404, 2003

72 Lupi C, "Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma" 92 : 4085-4090, 2007

73 Lee X, "Analysis of differential BRAF(V600E) mutational status in high aggressive papillary thyroid microcarcinoma" 16 : 240-245, 2009

74 Ito Y, "An observation trial without surgical treatment in patients with papillary microcarcinoma of the thyroid" 13 : 381-387, 2003

75 Black WC, "Advances in diagnostic imaging and overestimations of disease prevalence and the benefits of therapy" 328 : 1237-1243, 1993

76 Ito Y, "A therapeutic strategy for incidentally detected papillary microcarcinoma of the thyroid" 3 : 240-248, 2007