Estimation of the Biological Effectiveness of Auger Electron-Emitting Radiopharmaceuticals for Targeted Radiotherapy

다국어 초록 (Multilingual Abstract)

Relative biological effectiveness (RBE) plays an important role in relating physical dose to cell-killing biological dose. The calculation of the RBE is an important basic task in realization of radionuclide therapy using 64Cu. In this study, the method of calculating the RBE of emitted particles from 64Cu is presented using Monte Carlo simulation. U-87 MG cell model is designed to perform Monte Carlo simulation. The Geant4 simulation tool kit was used to simulate the secondary particles for transport into media. The specific energy in the cell nucleus and the domain was estimated. The Microdosimetric Kinetic model (MK model) is used to estimate RBE. The method presented in this study may be helpful to estimate biological dose in treatment with 64Cu.

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