Rehabilitation Nutrition and Exercise Therapy for Sarcopenia

다국어 초록 (Multilingual Abstract)

Sarcopenia is an age-related loss of skeletal muscle associated with adverse outcomes such as falls, fractures, disability, and increased mortality in older people and hospitalized patients. About half of older male nursing home residents have sarcopenia.
The diagnostic criteria by the European Working Group on Sarcopenia in Older People (EWGSOP) and the Asian Working Group for Sarcopenia (AWGS) have led to increased interest in sarcopenia. Exercise and nutritional management are crucial for the prevention and treatment of sarcopenia. Nutritional therapy for sarcopenia that includes 20 g of whey protein and 800 IU of vitamin D twice a day improves lower limb strength. Exercise therapy for sarcopenia, such as resistance training and 6 months of home exercises, improves muscle strength and physical function. Combination therapy that includes both nutritional and exercise therapy improves gait speed and knee extension strength more than either exercise alone or nutrition therapy alone. Excessive bedrest and mismanagement of nutrition in medical facilities can lead to iatrogenic sarcopenia.
Iatrogenic sarcopenia is sarcopenia caused by the activities of health care workers in health care facilities. Appropriate nutritional management and exercise programs through rehabilitation nutrition are important for prevention and treatment of iatrogenic sarcopenia. Nutritional and exercise therapy should be started very early after admission and adjusted to the level of inflammation and disease status. Repeated assessment, diagnosis, goal setting, interventions, and monitoring using the rehabilitation nutrition care process is important to maximize treatment effectiveness and improve patients’ functional recovery and quality of life.

참고문헌 (Reference)

1 Park H, "Yearlong physical activity and sarcopenia in older adults : the Nakanojo study" 109 : 953-961, 2010

2 Rondanelli M, "Whey protein, amino acids, and vitamin D supplementation with physical activity increases fat-free mass and strength, functionality, and quality of life and decreases inflammation in sarcopenic elderly" 103 : 830-840, 2016

3 Hua X, "When the loss costs too much : a systematic review and metaanalysis of sarcopenia in head and neck cancer" 9 : 1561-, 2020

4 Bravata DM, "Using pedometers to increase physical activity and improve health : a systematic review" 298 : 2296-2304, 2007

5 Diekmann R, "The role of nutrition in geriatric rehabilitation" 21 : 14-18, 2018

6 Moore FD, "The metabolic response to surgery" Charles C. Thomas 1952

7 Martone AM, "The incidence of sarcopenia among hospitalized older patients : results from the Glisten study" 8 : 907-914, 2017

8 Shen Y, "The impact of frailty and sarcopenia on postoperative outcomes in older patients undergoing gastrectomy surgery : a systematic review and metaanalysis" 17 : 188-, 2017

9 Maeda K, "Tentative nil per os leads to poor outcomes in older adults with aspiration pneumonia" 35 : 1147-1152, 2016

10 Iwamoto M, "Swallowing rehabilitation with nutrition therapy improves clinical outcome in patients with dysphagia at an acute care hospital" 61 : 353-360, 2014

11 Verlaan S, "Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults-the PROVIDE study" 37 : 551-557, 2018

12 Keller K, "Strength and muscle mass loss with aging process. Age and strength loss" 3 : 346-350, 2014

13 Cruz-Jentoft AJ, "Sarcopenia: revised European consensus on definition and diagnosis" 48 : 16-31, 2019

14 Cruz-Jentoft AJ, "Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People" 39 : 412-423, 2010

15 Hu X, "Sarcopenia predicts prognosis of patients with renal cell carcinoma : a systematic review and meta-analysis" 46 : 705-715, 2020

16 Pizzimenti M, "Sarcopenia and peripheral arterial disease : a systematic review" 11 : 866-886, 2020

17 Hunter GR, "Sarcopenia and its implications for metabolic health" 2019 : 8031705-, 2019

18 Fujishima I, "Sarcopenia and dysphagia : position paper by four professional organizations" 19 : 91-97, 2019

19 Fielding RA, "Sarcopenia : an undiagnosed condition in older adults. Current consensus definition : prevalence, etiology, and consequences. International Working Group on Sarcopenia" 12 : 249-256, 2011

20 Cruz-Jentoft AJ, "Sarcopenia" 393 : 2636-2646, 2019

21 Nagano A, "Respiratory sarcopenia and sarcopenic respiratory disability : concepts, diagnosis, and treatment" 2021

22 Nagano A, "Rehabilitation nutrition for iatrogenic sarcopenia and sarcopenic dysphagia" 23 : 256-265, 2019

23 Liao Y, "Prospective views for whey protein and/or resistance training against age-related sarcopenia" 10 : 157-173, 2019

24 Kim G, "Prognostic value of sarcopenia in patients with liver cirrhosis : a systematic review and meta-analysis" 12 : e0186990-, 2017

25 Li J, "Prognostic value of radiologically determined sarcopenia prior to treatment in urologic tumors: a meta-analysis" 98 : e17213-, 2019

26 Pacifico J, "Prevalence of sarcopenia as a comorbid disease : a systematic review and meta-analysis" 131 : 110801-, 2020

27 Cruz-Jentoft AJ, "Prevalence of and interventions for sarcopenia in ageing adults : a systematic review. Report of the International Sarcopenia Initiative(EWGSOP and IWGS)" 43 : 748-759, 2014

28 Xu BY, "Predictors of poor functional outcomes and mortality in patients with hip fracture : a systematic review" 20 : 568-, 2019

29 Charlton KE, "Older rehabilitation patients are at high risk of malnutrition : evidence from a large Australian database" 14 : 622-628, 2010

30 Wall BT, "Nutritional strategies to attenuate muscle disuse atrophy" 71 : 195-208, 2013

31 Visvanathan R, "Nutritional screening of older people in a sub-acute care facility in Australia and its relation to discharge outcomes" 33 : 260-265, 2004

32 Cruz-Jimenez M, "Normal changes in gait and mobility problems in the elderly" 28 : 713-725, 2017

33 Dirks ML, "Neuromuscular electrical stimulation prevents muscle wasting in critically ill comatose patients" 128 : 357-365, 2015

34 Moore FD, "Metabolic care of the surgical patient" W.B. Saunders 1959

35 Thomas DR, "Malnutrition in subacute care" 75 : 308-313, 2002

36 Strakowski MM, "Malnutrition in rehabilitation" 81 : 77-78, 2002

37 Chang KV, "Is sarcopenia associated with hepatic encephalopathy in liver cirrhosis? A systematic review and meta-analysis" 118 : 833-842, 2019

38 Chang KV, "Is sarcopenia associated with depression? A systematic review and metaanalysis of observational studies" 46 : 738-746, 2017

39 Yoshimura Y, "Interventions for treating sarcopenia : a systematic review and meta-analysis of randomized controlled studies" 18 : 553-, 2017

40 Dent E, "International clinical practice guidelines for sarcopenia(ICFSR) : screening, diagnosis and management" 22 : 1148-1161, 2018

41 Barreiro Domínguez E, "Impact of preoperative oral nutrition therapy in patients undergoing surgery for colorectal cancer" 36 : 1150-1156, 2019

42 Engel HJ, "ICU early mobilization : from recommendation to implementation at three medical centers" 41 (41): S69-80, 2013

43 Kemmler W, "Exercise, body composition, and functional ability : a randomized controlled trial" 38 : 279-287, 2010

44 Bao W, "Exercise programs for muscle mass, muscle strength and physical performance in older adults with sarcopenia : a systematic review and meta-analysis" 11 : 863-873, 2020

45 Akune T, "Exercise habits during middle age are associated with lower prevalence of sarcopenia : the ROAD study" 25 : 1081-1088, 2014

46 Piastra G, "Effects of two types of 9-month adapted physical activity program on muscle mass, muscle strength, and balance in moderate sarcopenic older women" 2018 : 5095673-, 2018

47 Binder EF, "Effects of progressive resistance training on body composition in frail older adults : results of a randomized, controlled trial" 60 : 1425-1431, 2005

48 Nagano A, "Effects of physical rehabilitation and nutritional intake management on improvement in tongue strength in sarcopenic patients" 12 : 3104-, 2020

49 Hsu KJ, "Effects of exercise and nutritional intervention on body composition, metabolic health, and physical performance in adults with sarcopenic obesity : a meta-analysis" 11 : 2163-, 2019

50 Antoniou GA, "Effect of low skeletal muscle mass on post-operative survival of patients with abdominal aortic aneurysm : a prognostic factor review and meta-analysis of time-to-event data" 58 : 190-198, 2019

51 Maruya K, "Effect of a simple and adherent home exercise program on the physical function of community dwelling adults sixty years of age and older with pre-sarcopenia or sarcopenia" 28 : 3183-3188, 2016

52 Burtin C, "Early exercise in critically ill patients enhances short-term functional recovery" 37 : 2499-2505, 2009

53 Koyama T, "Early commencement of oral intake and physical function are associated with early hospital discharge with oral intake in hospitalized elderly individuals with pneumonia" 63 : 2183-2185, 2015

54 Weimann A, "ESPEN guidelines on enteral nutrition : surgery including organ transplantation" 25 : 224-244, 2006

55 Papadopoulou SK, "Differences in the prevalence of sarcopenia in community-dwelling, nursing home and hospitalized individuals. A systematic review and meta-analysis" 24 : 83-90, 2020

56 Tieland M, "Dietary protein intake in community-dwelling, frail, and institutionalized elderly people : scope for improvement" 51 : 173-179, 2012

57 Maeda K, "Development and predictors of sarcopenic dysphagia during hospitalization of older adults" 12 : 70-, 2019

58 Fearon K, "Definition and classification of cancer cachexia : an international consensus" 12 : 489-495, 2011

59 Jubrias SA, "Decline in isokinetic force with age : muscle cross-sectional area and specific force" 434 : 246-253, 1997

60 Arai H, "Chapter 4 Treatment of sarcopenia" 18 (18): 28-44, 2018

61 Evans WJ, "Cachexia : a new definition" 27 : 793-799, 2008

62 Chang KV, "Association between sarcopenia and cognitive impairment : a systematic review and meta-analysis" 17 : 1164-, 2016

63 Agmon M, "Association between 900 steps a day and functional decline in older hospitalized patients" 177 : 272-274, 2017

64 Nakahara S, "Aggressive nutrition therapy in malnutrition and sarcopenia" 84 : 111109-, 2021

65 Hébuterne X, "Ageing and muscle : the effects of malnutrition, re-nutrition, and physical exercise" 4 : 295-300, 2001

66 Villareal DT, "Aerobic or resistance exercise, or both, in dieting obese older adults" 376 : 1943-1955, 2017

67 Gariballa SE, "A randomized, controlled, a single-blind trial of nutritional supplementation after acute stroke" 22 : 315-319, 1998

68 Chen LK, "2019consensus update on sarcopenia diagnosis and treatment" 21 : 300-307, 2020