Analysis of Effect of Eggshell Membrane Patching for Moderate-to-Large Traumatic Tympanic Membrane Perforation

다국어 초록 (Multilingual Abstract)

Background and Objectives: To evaluate the effect of eggshell membrane (ESM) patching for tympanic membrane (TM) perforation, and to investigate correlations between healing time and age, gender, patching time, perforation size, and perforation location. Subjects and Methods: One hundred and seventy-five patients diagnosed with traumatic TM perforation at the Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Ansan Hospital, between January 2008 and October 2013. Patients were divided into two groups, according to perforation edge approximation or ESM patching treatment. Healing time was compared between the group that received perforation edge approximation and the group that received ESM patching. Perforation grade, age, onset, and location were also compared between the two groups. Results: ESM patching significantly improved healing time compared to spontaneous healing, especially in patients with moderate or large traumatic TM perforations (≥grade II). However, patient age, gender, perforation location, and especially timing of procedure, did not significantly affect healing time. Conclusions: ESM patching can be a good treatment choice to promote tympanic membrane healing in large traumatic TM perforations.

참고문헌 (Reference)

1 Cheng T, "Viscoelastic properties of human tympanic membrane" 35 : 305-314, 2007

2 Sprem N, "Tympanoplasty after war blast lesions of the eardrum: retrospective study" 42 : 642-645, 2001

3 Kim JH, "Tympanic membrane regeneration using a water-soluble chitosan patch" 16 : 225-232, 2010

4 Ritenour AE, "Tympanic membrane perforation and hearing loss from blast overpressure in Operation Enduring Freedom and Operation Iraqi Freedom wounded" 64 : S174-S178, 2008

5 Lou ZC, "Traumatic tympanic membrane perforations:a study of etiology and factors affecting outcome" 33 : 549-555, 2012

6 Hempel JM, "Traumatic tympanic membrane perforations: clinical and audiometric findings in 198 patients" 33 : 1357-1362, 2012

7 Camnitz PS, "Traumatic perforations of the tympanic membrane:early closure with paper tape patching" 93 : 220-223, 1985

8 Torres FG, "Structure-property relationships of a biopolymer network: the eggshell membrane" 6 : 3687-3693, 2010

9 Saito H, "Simple maneuver for closing traumatic eardrum perforation by micropore strip tape patching" 11 : 427-430, 1990

10 Parekh A, "Repair of the tympanic membrane with urinary bladder matrix" 119 : 1206-1213, 2009

11 Golz A, "Paper patching for chronic tympanic membrane perforations" 128 : 565-570, 2003

12 Conoyer JM, "Otologic surgery following ear trauma" 137 : 757-761, 2007

13 Lasak JM, "Middle ear injury through the external auditory canal: a review of 44 cases" 85 : 722-, 2006

14 Lim DJ, "Human tympanic membrane. An ultrastructural observation" 70 : 176-186, 1970

15 Orji FT, "Determinants of spontaneous healing in traumatic perforations of the tympanic membrane" 33 : 420-426, 2008

16 Kim J, "Comparison of methods for the repair of acute tympanic membrane perforations:silk patch vs. paper patch" 18 : 132-138, 2010

17 Hakuba N, "Basic fibroblast growth factor combined with atelocollagen for closing chronic tympanic membrane perforations in 87 patients" 31 : 118-121, 2010

18 Griffin WL Jr, "A retrospective study of traumatic tympanic membrane perforations in a clinical practice" 89 : 261-282, 1979

19 Lou ZC, "A randomised controlled trial comparing spontaneous healing, gelfoam patching and edge-approximation plus gelfoam patching in traumatic tympanic membrane perforation with inverted or everted edges" 36 : 221-226, 2011

20 Jun HJ, "A new patch material for tympanic membrane perforation by trauma: the membrane of a hen egg shell" 134 : 250-254, 2014