한인진 추출물의 간장보호 작용에 관한 연구 = A Study on the Hepatoprotective effect of PS-1 from Artemisia iwayomogi

다국어 초록 (Multilingual Abstract)

The dose-response effect of polysaccharide extracts(PS-1) from Artemisia iwayomogi was investigated under various hepatic disease models. Silymarin, DDB and UDCA were used as reference compounds. We found that the maximal effective dose of PS-1 was 100 ㎎/㎏ b.wt. in CCl_4-induced hepatotoxicity, D-galactosamine-induced hepatitis, in ANIT-induced cholestasis and 300 ㎎/㎏ b.wt. in CCl_4-induced chronic liver disease, 30 ㎎/㎏ b.wt. in chronic bile duct ligation and chronic ethanol fatty liver. These findings suggest that PS-1 fraction protects the hepatocyte against various hepatic injuries, and this fracton might be of therapeutic value.

목차 (Table of Contents)

• 실험 방법
• 실험동물
• 시험물질
• CCl_4간장해
• D-Galactosamine 간염
• 담즙을체
• 지방간
• CCl_4 만성간장해
• 담도결찰에 의한 간섬유화
• 알콜성 지방간
• 통계처리
• 실험결과
• CCI_4 간장해
• D-Galartosamine 간염
• 담즙을체
• 지방간
• CCl_4 만성간장해
• 담도결찰에 의한 간섬유화
• 알콜성 지방간
• 고찰