한국인 혈관성 치매환자에서 아포지단백 E ε4 대립유전자형의 발현빈도 = Apolipoprotein E ε4 allele frequency in Korean Patients with Vascular Dementia

다국어 초록 (Multilingual Abstract)

Background: The clinical significance of the apolipoprotein E (Apo E) ε4 allele in vascular dementia (VaD) has been a subject of debate. VaD is the most common subtype of dementia in Korean population. Apo E allele frequencies were evaluated in Korean patients with VaD diagnosed by the Erkinjuntti criteria of subcortical vascular dementia and mini-mental-state examination(MMSE) in this study Methods: Forty patients participated in the study. 20 patients with VaD and 20 controls with no risk factors for stroke who had absolutely normal brain MRI findings The Apo E genotype was determined by the polymerase chain reaction (PCR) and allele specific hybridization using the Apo E typing test kit Results: The Apo E ε4 allele frequency in the VaD group was 20% and was not significantly different from those of normal controls (15%) The severity of dementia assessed by K-MMSE was not different between the VaD patients with Apo E ε4 allele and the VaD patients without Apo E ε4 allele Conclusions: These results did not show neither increased frequency of Apo E ε4 allele in Korean VaD patients, nor any differences in trends compared to control subjects.