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      KCI등재 SCOPUS SCIE

      대상포진후 신경통 환자에서 Magnesium 지속정주의 효과 = The Effect of the Continuous Intravenous Infusion of Magnesium for the Treatment of Postherpetic Neuralgia

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      https://www.riss.kr/link?id=A104351119

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      다국어 초록 (Multilingual Abstract)

      Postherpetic neuralgia (PHN) is a chronic pain syndrome associated with the reactivation of a primary varicella zoster virus infection and is one of the most serious complication of herpetic zoster. The clinical features of PHN are ongoing pain accompanied by allodynia, hyperalgesia, and paresthesia. Current treatment options aimed at relieving the symptoms of PHN include oral agents, such as, opioid, NSAIDs, antidepressants, anticonvulsants. And local anesthetics with steroids are used for subcutaneous infiltration, somatic nerve block, sympathetic nerve block and epidural nerve block. However, in some cases, the pain does not respond to this treatment. We report a case in which a patient suffering from PHN did not respond to conventional therapy, but in whom continuous intravenous infusion of magnesium and physiologic N-methyl-D-aspartate (NMDA) receptor antagonist, reduced severe pain.
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      Postherpetic neuralgia (PHN) is a chronic pain syndrome associated with the reactivation of a primary varicella zoster virus infection and is one of the most serious complication of herpetic zoster. The clinical features of PHN are ongoing pain accom...

      Postherpetic neuralgia (PHN) is a chronic pain syndrome associated with the reactivation of a primary varicella zoster virus infection and is one of the most serious complication of herpetic zoster. The clinical features of PHN are ongoing pain accompanied by allodynia, hyperalgesia, and paresthesia. Current treatment options aimed at relieving the symptoms of PHN include oral agents, such as, opioid, NSAIDs, antidepressants, anticonvulsants. And local anesthetics with steroids are used for subcutaneous infiltration, somatic nerve block, sympathetic nerve block and epidural nerve block. However, in some cases, the pain does not respond to this treatment. We report a case in which a patient suffering from PHN did not respond to conventional therapy, but in whom continuous intravenous infusion of magnesium and physiologic N-methyl-D-aspartate (NMDA) receptor antagonist, reduced severe pain.

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      참고문헌 (Reference)

      1 Crosby V, "The safety and efficacy of a single dose(500 mg or 1 g)of intravenous magnesium sulfate in neuropathic pain poorly responsive to strong opioid analgesics in patients with cancer" 19 : 35-9, 2000

      2 Kvarnstrom A, "The effectiveness of intra venous ketamine and lidocaine on peripheral neuropathic pain" 47 : 868-77, 2003

      3 Lee YB, "The effect of continous intravenous infusion of ketamine in the treatment of post- herpetic neuralgia" 31 : 654-7, 1996

      4 Tramer MR, "Role of magnesium sulfate in postoperative analgesia" 84 : 340-7, 1996

      5 Eide PK, "Relief of post-herpetic neuralgia with the N-methyl-D-aspatric acid receptor antagonist ketamine cross-over comparison with morphine and placebo" 347-54,

      6 Baron R, "Post-herpetic neuralgia case study:optimizing pain control" 11 : 3-11, 2004

      7 Bae WH, "Pain management of post- herpetic neuralgia" 1 : 9-15, 1988

      8 Felsby S, "NMDA receptor blockade in chronic neuropa thic pain:a comparison of ketamine and magnesium chloride" 64 : 283-91, 1996

      9 Dickenson AH, "NMDA receptor and central hyperalgesic states" 46 : 344-6, 1991

      10 Kim HG, "Management of herpes zoster and postherpetic neuralgia" 2 : 129-34, 1989

      1 Crosby V, "The safety and efficacy of a single dose(500 mg or 1 g)of intravenous magnesium sulfate in neuropathic pain poorly responsive to strong opioid analgesics in patients with cancer" 19 : 35-9, 2000

      2 Kvarnstrom A, "The effectiveness of intra venous ketamine and lidocaine on peripheral neuropathic pain" 47 : 868-77, 2003

      3 Lee YB, "The effect of continous intravenous infusion of ketamine in the treatment of post- herpetic neuralgia" 31 : 654-7, 1996

      4 Tramer MR, "Role of magnesium sulfate in postoperative analgesia" 84 : 340-7, 1996

      5 Eide PK, "Relief of post-herpetic neuralgia with the N-methyl-D-aspatric acid receptor antagonist ketamine cross-over comparison with morphine and placebo" 347-54,

      6 Baron R, "Post-herpetic neuralgia case study:optimizing pain control" 11 : 3-11, 2004

      7 Bae WH, "Pain management of post- herpetic neuralgia" 1 : 9-15, 1988

      8 Felsby S, "NMDA receptor blockade in chronic neuropa thic pain:a comparison of ketamine and magnesium chloride" 64 : 283-91, 1996

      9 Dickenson AH, "NMDA receptor and central hyperalgesic states" 46 : 344-6, 1991

      10 Kim HG, "Management of herpes zoster and postherpetic neuralgia" 2 : 129-34, 1989

      11 Stankus SJ, "Management of herpes zoster" 2437 2447-44 8, 2000

      12 Fawcett WJ, "Magnesium:physiology and pharmacology" 83 : 302-20, 1999

      13 Xiao WH, "Magnesium suppresses neuropathic pain responses in rats via a spinal site of action" 666 : 168-72, 1994

      14 McKendrick MW, "Lack of effect of acyclovir on postherpetic neuralgia" 298 : 431-, 1989

      15 Song SO, "Is an epidural steroid injection with an addition of an intravenous and intradermal injection of lidocaine advantageous in the pain management of herpes zoster" 594-9, 2002

      16 Mauskop A, "Intravenous magnesium sulfate relieves migraine attacks in patients with low serum ionized magnesium levels" 633-6, 1995

      17 Loeser JD, "Herpes zoster and postherpetic neuralgia" 25 : 149-64, 1986

      18 Brill S, "Efficacy of intravenous magnesium in neuropathic pain" 89 : 711-4, 2002

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