矮小條蟲(Hymenolepis nana)에 대한 Albendazole의 영향에 관한 電子顯微鏡的 硏究 = Electron Microscopic Study on the Effect of Albendazole against Hymenolepis nana

다국어 초록 (Multilingual Abstract)

Newly developed albendazole (Zentel®) is a broad spectrum anthelmintic with high activity against intestinal nematodes as well as trematodes and cestodes infections. The present study was undertaken to observe the morphological changes of Hymenolepis nana which obtained from experimentally infected mice after treatment with albendazole. For this study 20 mice were artificially infected with eggs and 16 of them were given albendazole (1×100mg/kg) four weeks after infection. The worms were collected from the small intestine of the mice which were autopsied at 1 and 2 hours after treatment. The fine structure of the collected worms were studied by means of scanning and transmission electron microscopies. The findings were compared with those of untreated worms. The results are as follows:
1. The worms obtained from non-treated mice showed that the whole surface is covered with many microtriches. Microtriches of H. nana may be divided into three anatomical regions; a base, junctional region and cap. Tegumental layer showed well developed syncytium which included a lot of number of discoidal secretory bodies.
2. Many blebs were formed on the surface of the damaged tegument of the worm at 1 hour after treatment with albendazole. The bleb was packed by plasma membrance and included matrix which uniform electron density. Some bleb surface has microtriches.
3. The destruction of tegumental syncytium was recognized at 2 hours after treatment with albendazole. Therefore the blebs on the worm sufrace caused to the death by the tegumatal bursing.