계피추출물이 시상하부-뇌하수체-부신축의 조절효과 = Control Effect of Hypothalamic-Pituitary-Adrenal Axis with Cinnamon(Cinnamomum japonicum) Extract

다국어 초록 (Multilingual Abstract)

Cinnamomum japonicum(CCE) is a genus of plants in the family Cinnamomum. Traditionally CCE has been already used for traditional medicine in Korea. But the study about antidepressant-like activity and related molecular mechanisms of CCE were not studied well. The effects of subacute treatment with CCE(100 and 200 mg/kg, p.o.) on immobility and FST-induced changes of immune parameters were investigated by using the forced swimming test (FST) in rats. As a result, CCE immobility decreases with a dose-dependency in the FST. The levels of cortisol, IL-6, IL-1β, and TNF-α of treatment group were significantly decreased than those of the FST group. Similarly p-p65 and p-65 activity of treatment group were decreased than those of the FST group. In all, these results indicate that CCE extract can be a very effective treatment for depression, suggesting that The down-regulation of NFkB activity is related to Antidepressant Effect of Berchemia berchemiaefolia.

국문 초록 (Abstract)

계피껍질은 녹나무속에 속하는 식물로서 전통약재로 사용되어 왔다. 그러나 항우울효과 및 그에 대한 분자기전에 대한 연구는 미흡한 실정이다. 100, 200 mg/kg 용량의 계피추출물을 쥐실험군에게 경구투여한 후 변화하는 부동시간의 변화와 면역변화를 분석함으로 추출물의 효능을 알고자 본 실험을 실행하였다. 그 결과 경구투여한 추출물의 농도에 비례하여 부동시간, 코티솔농도, 그리고 IL-6, IL-1β, TNF-α 같은 전염증성사이토카인의 농도가 감소하였다. 이와 유사한 경향으로 p-p65과 p-65의 활성도 역시 계피추출물 경구투여군이 비투여실험군에 비하여 감소하였다. 위의 결과를 종합하여 볼 때 계피 추출물은 우울증에 효과적인 치료제가 될 수 있는 경쟁력 있는 물질이며 이러한 항우울효과는 NFkB 활성 저하조절과 관련이 있다고 간주된다.

참고문헌 (Reference)

1 National Center for Complementary and Alternative Medicine (NCCAM), 463 : 231-240, 2012

2 U. Gowda, "Vitamin D supplementation to reduce depression in adults: Meta-analysis of randomized controlled trials" 31 (31): 421-429, 2015

3 J. Chun, "Ursolic acid inhibits nuclear factor-κB signaling in intestinal epithelial cells and macrophages, and attenuates experimental colitis in mice" 110 : 23-34, 2014

4 D. Borsook, "Understanding migraine through the lens of maladaptive stress responses: a model disease of allostatic load" 73 : 219-234, 2012

5 A. E. Nmt, "Therapeutic effect of onion (allium cepa) and cinnamon oils on cryptosporidiosis in experimentally infected mice" 7 : 179-183, 2011

6 E. Oglodek, "The role of the neuroendocrine and immne system in the pathogenesis of depression" 66 : 776-781, 2014

7 H. Erick, "Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy" 358 : 252-260, 2008

8 Steven Moylana, "Oxidative & nitrosative stress in depression:Why so much stress?" 45 : 62-, 2014

9 S. Aradhya, "NF-kappaB signaling and human disease" 11 (11): 300-306, 2001

10 J. W. Kim, "Inflammatory markers and the pathogenesis of pediatric depression and suicide: a systematic review of the literature" 75 (75): 1242-1253, 2014

11 H. Andrew, "Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression" 65 : 732-741, 2009

12 T. W. Pace, "Increased peripheral NF-κB pathway activity in women with childhood abuse-related posttraumatic stress disorder" 26 (26): 13-17, 2012

13 S. Chericoni, "In vitro activity of the essential oil of cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes" 53 : 4762-4765, 2005

14 C. Gragnoli, "Hypothesis of the neuroendocrine cortisol pathway gene role in the comorbidity of depression, type 2 diabetes, metabolic syndrome" 12 : 43-53, 2014

15 V. D. Filip, "Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome" 231 : 112-120, 2007

16 P. Ranasinghe, "Efficacy and safety of ‘true’ cinnamon (cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis" 29 : 1480-1492, 2012

17 R. Akilen, "Effect of short-term administration of cinnamon on blood pressure in patients with prediabetes and type 2 diabetes" 29 (29): 1192-1196, 2013

18 M. R. Irwin, "Depressive disorders and immunity: 20 years of progress and discovery" 21 : 374-383, 2007

19 L. R Charles, "Cytokines sing the blues: inflammation and the pathogenesis of depression" 27 : 121-129, 2006

20 M. Naughton, "Corticotropin-releasing hormone and the hypothalamic–pituitary–adrenal axis in psychiatric disease" 124 : 69-91, 2014

21 G. Thomas, "Chronic S tress and the HPA Axis: Clinical Assessment and Therapeutic Considerations" 9 : 211-220, 2010

22 P. Nyadjeu, "Antihypertensive and vasorelaxant effects of cinnamomumzeylanicum stem bark aqueous extract in rats" 8-, 2011

23 E. Walum, "Acute oral toxicity" 106 : 497-503, 1998

24 M. Yoneyama, "Activation of neuronal regeneration signal following neuronal degeneration-involve ment of microglia" 142 (142): 17-21, 2013

25 C. Bockting, "A lifetime approach to major depressive disorder: The contributions of psychological interventions in preventing relapse and recurrence" 15 : 272-281, 2015