Four to five rabbits weighing about 2 kg either intact, anesthetized with urethane, or hypertonized with catecholamine, were wed to study the sympathicolytic action of chlorpromazine, i.e. depressor effect which might in part be the cause of the sympa...
Four to five rabbits weighing about 2 kg either intact, anesthetized with urethane, or hypertonized with catecholamine, were wed to study the sympathicolytic action of chlorpromazine, i.e. depressor effect which might in part be the cause of the sympathicotonic action, for example chlorpromazine hyperglycemia.
Blood pressure of carotid artery was measured by the usual mercury-citrate manometer system and was recorded on a smoked drum.
An ear vessel of rabbit was perfused with 0.5% chlorpromazine solution according to Krakow-Pissemski's method to study how peripheral vessels respond directly to chlorpromazine.
The results are as follows.
1. Chlorpromazine decreases the blood pressure of healthy rabbit.
2. Urethane anesthesia potentiates the depressor effect of chlorpromazine.
3. Chlorpromazine inhibits the pressor effect of adrenaline and noradrenaline.
4. Chlorpromazine dilates the peripheral ear Mood vessels.