OK-432의 종양 내 주입 후 완전 절제한 흉부 종양 치험(2례) = Compelete Surgical Resection of Inoperable Chest Tumors After Intratumoral Injection of OK-432

다국어 초록 (Multilingual Abstract)

OK-432, a penicillin-killed and lyophilized preparation of a low-virulence strain of Streptococcus pyogenes, stimulated dendritic cells can produce interleukin(IL)-12 and interferon(IFN)-ϓ, which are potent cytokines that mediate T-helper 1(Th1) cell development. Japan and Korea have been successfully used as the pleurodesis agent in malignant effusion and immunotheraputic agent of Biologic Response Modifiers in cancer. It is considered that this strategy is useful for clinical applications as a cancer vaccine therapy for patients with CEA-expressing gastrointestinal tumors. Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. It is the report for two patients whose advanced metastatic lung cancers from osteosarcoma and invasive thymoma are inoperable. We have treated surgically t재 cases by injecting intratumor to decrease the size of tumor.

목차 (Table of Contents)

• 서론
• 증례
• 고찰
• 참고문헌

참고문헌 (Reference)

1 Ojima T, "Streptococcal preparation OK-432 promotes the capacity of dendritic cells(DCs) to prime carcinoembryonic antigen(CEA)-specific cytotoxic T lymphocyte responses induced with genetically modified DCs that express CEA" 32 : 459-466, 2008

2 Suzuki K, "Postoperative Mediastinal Chyloma" 68 : 1858-1860, 1999

3 Homma S, "Mechanism of antitumor effect on mousehepatocellular carcinoma by intratumoral injection of OK-432, a streptococcal preparation" 56 : 1265-1274, 2007

4 Okamoto M, "Involvement of Toll-Like Receptor 4 Signaling in Interferon-gamma Production and Antitumor Effect by Streptococcal Agent OK-432" 95 : 316-326, 2003

5 Yokomise H, "Autoblood Plus OK-432 Pleurodesis With Open Drainage for Persistent Air Leak After Lobectomy" 65 : 563-565, 1998