Resepine과 Human Chorionic Gonadotropin 이 家兎의 子宮및 골격근조직내 Catecholamine 含量에 미치는 影響 = An Experimental Study on Catecholamine Content in the Uterine and Skeletal Muscle Tissue of Mature Female Rabbits by Reserpine and Human Chorionic Gonadotropin Administration

다국어 초록 (Multilingual Abstract)

Catecholamine has various pharmacological effects. This might be due largely to its relation to the sympathetic nervous system. Reserpine has been widely used as a tranquilizer and anti-hypertensive drug in the obstetrical and gynecological field for last 20 years in spite of a number of untoward side effects affecting various organs.
An attempt has been made to clarify the effects of reserpine on the catecholamine content in the uterine and skeletal muscle tissue of mature female albino rabbits weighing around 2㎏.
A group of albino rabbits conditioned with 50 I.U./㎏ of H.C.G. and another group with 1.0㎎/㎏ of reserpine plus 50 I.U./㎏ of H.C.G. were observed in 24 hours after conditioning.
Catecholamine content was determined by Shore and Olin method.
The results obtained were as as follows:
1. The catecholamine content in the normal uterine tissue was 0.40 ㎍/gm, while that of the skeletal muscle tissue was 0.11 ㎍/gm. Therefore catecholamine content in the uterine tissue was much higher than that in the skeletal muscle tissue.
2. In the H.C.G. conditioned group, the catecholamine content in the uterine tissue showed decrease in content (0.13 ㎍/gm) as compared to the normal group and in the skeletal muscle tissue it showed a decrease (0.07 ㎍/gm) as compared to the normal rabbit group.
3. In the reserpine plus H.C.G. conditioned group, the catecholamine content in the uterine tissue was much more decreased in content(0.06 ㎍/gm) and the content in the skeletal muscle tissue showed a decrease (0.07 ㎍/gm) as compared to the normal rabbit group.
4. The catecholamine content in the uterine tissue showed decrease if treated with H.C.G. and much more decreased in the reserpine plus H.C.G. conditioned group.
5. The catecholamine content in the skeletal muscle tissue treated with H.C.G. and reserpine plus H.C.G. showed a decrease as compared to the normal rabbit group.
6. In the normal group, the catecholamine content in the uterine tissue was much higher than that in the skeletal muscle tissue and in the H.C.G. conditioned group, the catecholamine content in the uterine tissue was higher than that in the skeletal muscle tissue. In the reserpine plus H.C.G. conditioned group, the catecholamine content in he skeletal muscle tissue showed almost the same as that in the uterine tissue,

목차 (Table of Contents)

• Ⅰ. 緖論
• Ⅱ. 實驗資料 및 方法
• 1. 實驗動物
• 2. Human Chorionic Gonadotropine 및 Reserpine 投與方法
• 3. Catecolamine의 測定方法
• Ⅲ. 實驗成績
• 1. 正常子宮 및 骨격筋 組織內 Catecholamine 含量
• 2. H.C.G. 投與後 子宮및 骨격筋 組織內 Catecholamine 含量의 比較
• 3. H.C.G 및 Reserpine 投與後 子宮 및 골격근 組織內 Catecholamine 含量의 比較
• 4. 子宮組織內 Catecholamine 含量의 比較
• 5. 骨격筋組織內 Catecholamine 含量의 比較
• 6. 子宮 및 骨격筋組織內 Catecholamine 含量의 比較
• Ⅳ. 考按
• Ⅴ. 結論
• 參考文獻