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      Age-related Changes in Luteinizing Hormone and Testosterone Levels in Korean Men = 한국 남성의 혈중 Luteinizing Hormone과 Testosterone 수준의 연령-관련 변화

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      https://www.riss.kr/link?id=A100234378

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      국문 초록 (Abstract)

      한국 남성의 연령 증가에 따른 혈중 luteinizing hormone(LH), testosterone(T), 그리고 타액 T 수준 변화를 조사하였다. 혈중LH 수준은 40대까지 유의한 변화를 보이지 않았으나(20s, ; 30s, ; and 40s, ), 50대 이상에서 유의하게 증가하였다(50s, and 60s, ). 또한, 혈중 T 수준도 40대까지는 변화하지 않았으나(20s, , 30s, , 40s, ng/mL), 50대 이후 유의하게 감소하였다(
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      한국 남성의 연령 증가에 따른 혈중 luteinizing hormone(LH), testosterone(T), 그리고 타액 T 수준 변화를 조사하였다. 혈중LH 수준은 40대까지 유의한 변화를 보이지 않았으나(20s, ; 30s, ; and 40s, ), 50대 ...

      한국 남성의 연령 증가에 따른 혈중 luteinizing hormone(LH), testosterone(T), 그리고 타액 T 수준 변화를 조사하였다. 혈중LH 수준은 40대까지 유의한 변화를 보이지 않았으나(20s, ; 30s, ; and 40s, ), 50대 이상에서 유의하게 증가하였다(50s, and 60s, ). 또한, 혈중 T 수준도 40대까지는 변화하지 않았으나(20s, , 30s, , 40s, ng/mL), 50대 이후 유의하게 감소하였다(

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      다국어 초록 (Multilingual Abstract)

      Changes in luteinizing hormone (LH), serum testosterone (T), and salivary T levels with age were examined in Korean men. Serum was obtained from 167 Korean men of different ages (), and the serum LH and T levels were measured. Saliva samples were also obtained, and the salivary T level was determined. The LH levels did not change considerably until 40 y of age (20s, ; 30s, ; and 40s, ) but increased significantly around 50 y (50s, and 60s, ). Further, the serum T levels also did not change until 40 y of age (20s, , 30s, , 40s, ) but decreased significantly at 50 y (50s, ; 60s, ). The salivary T levels also showed small changes until the age of 40 y (, ) but decreased significantly at 50 y (). Thus, the relative ratio of salivary T to serum T levels did not change significantly in all the ages examined (). Linear regression analysis predicted that the LH levels increased 1.5%/y while the serum and salivary T levels decreased 1%/y and 0.8%/y, respectively. The serum T/LH ratio did not change considerably until the age of 40 y (, ) but decreased significantly () at 50 y. Age-related changes in the salivary T/LH ratio were very similar to those in the serum T/LH ratio. These results demonstrated that LH and T levels in serum or saliva did not change considerably until 40 y of age; instead, in Korean men, from 50 y of age, the LH level increased, while the T level decreased. This suggests that primary testicular failure that occurred due to aging (approximately 50 y) and caused this phenomenon. The present study also shows that the salivary T level can be an indicator of the free T level in serum although the salivary T level correlates weakly with the total T level in serum (r=0.53). Thus, information regarding salivary T levels may be useful for studying the age-related changes occurring in male testicular physiology.
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      Changes in luteinizing hormone (LH), serum testosterone (T), and salivary T levels with age were examined in Korean men. Serum was obtained from 167 Korean men of different ages (), and the serum LH and T levels were measured. Saliva samples were also...

      Changes in luteinizing hormone (LH), serum testosterone (T), and salivary T levels with age were examined in Korean men. Serum was obtained from 167 Korean men of different ages (), and the serum LH and T levels were measured. Saliva samples were also obtained, and the salivary T level was determined. The LH levels did not change considerably until 40 y of age (20s, ; 30s, ; and 40s, ) but increased significantly around 50 y (50s, and 60s, ). Further, the serum T levels also did not change until 40 y of age (20s, , 30s, , 40s, ) but decreased significantly at 50 y (50s, ; 60s, ). The salivary T levels also showed small changes until the age of 40 y (, ) but decreased significantly at 50 y (). Thus, the relative ratio of salivary T to serum T levels did not change significantly in all the ages examined (). Linear regression analysis predicted that the LH levels increased 1.5%/y while the serum and salivary T levels decreased 1%/y and 0.8%/y, respectively. The serum T/LH ratio did not change considerably until the age of 40 y (, ) but decreased significantly () at 50 y. Age-related changes in the salivary T/LH ratio were very similar to those in the serum T/LH ratio. These results demonstrated that LH and T levels in serum or saliva did not change considerably until 40 y of age; instead, in Korean men, from 50 y of age, the LH level increased, while the T level decreased. This suggests that primary testicular failure that occurred due to aging (approximately 50 y) and caused this phenomenon. The present study also shows that the salivary T level can be an indicator of the free T level in serum although the salivary T level correlates weakly with the total T level in serum (r=0.53). Thus, information regarding salivary T levels may be useful for studying the age-related changes occurring in male testicular physiology.

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      참고문헌 (Reference)

      1 Christ-Crain M, "Value of gonadotropin-releasing hormone testing in the differential diagnosis of androgen deficiency in elderly men" 90 : 1280-1286, 2005

      2 Morley JE, "Validation of salivary testosterone as a screening test for male hypogonadism" 9 : 165-169, 2006

      3 Albertsson-Wikland K, "Twenty-four-hour profiles of luteinizing hormone, follicle-stimulating hormone, testosterone, and estradiol levels: a semilongitudinal study throughout puberty in healthy boys" 82 : 541-549, 1997

      4 Simon D, "The influence of aging on plasma sex hormones in men: the Telecom Study" 135 : 783-791, 1992

      5 Sparrow D, "The influence of age, alcohol consumption, and body build on gonadal function in men" 51 : 508-512, 1980

      6 Lamberts SW, "The endocrinology of aging" 278 : 419-424, 1997

      7 Lukas WD, "Testosterone, aging, and body composition in men from Harare, Zimbabwe" 16 : 704-712, 2004

      8 Sannikka E, "Testosterone concentrations in human seminal plasma and saliva and its correlation with non-protein-bound and total testosterone levels in serum" 6 : 319-330, 1983

      9 Quissell DO, "Steroid hormone analysis in human saliva" 694 : 143-145, 1993

      10 Ferrini RL, "Sex hormones and age: a cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men" 147 : 750-754, 1998

      1 Christ-Crain M, "Value of gonadotropin-releasing hormone testing in the differential diagnosis of androgen deficiency in elderly men" 90 : 1280-1286, 2005

      2 Morley JE, "Validation of salivary testosterone as a screening test for male hypogonadism" 9 : 165-169, 2006

      3 Albertsson-Wikland K, "Twenty-four-hour profiles of luteinizing hormone, follicle-stimulating hormone, testosterone, and estradiol levels: a semilongitudinal study throughout puberty in healthy boys" 82 : 541-549, 1997

      4 Simon D, "The influence of aging on plasma sex hormones in men: the Telecom Study" 135 : 783-791, 1992

      5 Sparrow D, "The influence of age, alcohol consumption, and body build on gonadal function in men" 51 : 508-512, 1980

      6 Lamberts SW, "The endocrinology of aging" 278 : 419-424, 1997

      7 Lukas WD, "Testosterone, aging, and body composition in men from Harare, Zimbabwe" 16 : 704-712, 2004

      8 Sannikka E, "Testosterone concentrations in human seminal plasma and saliva and its correlation with non-protein-bound and total testosterone levels in serum" 6 : 319-330, 1983

      9 Quissell DO, "Steroid hormone analysis in human saliva" 694 : 143-145, 1993

      10 Ferrini RL, "Sex hormones and age: a cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men" 147 : 750-754, 1998

      11 Okamura K, "Serum total and free testosterone level of Japanese men: a population-based study" 12 : 810-814, 2005

      12 Neaves WB, "Seminiferous tubules and daily sperm production in older adult men with varied numbers of Leydig cells" 36 : 301-308, 1987

      13 Ohzeki T, "Salivary testosterone concentrations in prepubertal and pubertal males: comparison with total and free plasma testosterone" 36 : 235-237, 1991

      14 Kirschbaum C, "Salivary cortisol in psychoneuroendocrine research: recent developments and applications" 19 : 313-333, 1994

      15 Ahn RS, "Salivary cortisol and DHEA levels in the Korean population: age-related differences, diurnal rhythm, and correlations with serum levels" 30 : 379-388, 2007

      16 Harman SM, "Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin" 51 : 35-40, 1980

      17 Harman SM, "Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone and Leydig cell response to human chorionic gonadotropin" 51 : 35-41, 1980

      18 Mulligan T, "Pulsatile iv infusion of recombinant human LH in leuprolide-suppressed men unmasks impoverished Leydig-cell secretory responsiveness to midphysiological LH drive in the aging male" 86 : 5547-5553, 2001

      19 Ellison PT, "Population variation in age-related decline in male salivary testosterone" 17 : 3251-3253, 2002

      20 Veldhuis JD, "Mechanisms of ensemble failure of the male gonadal axis in aging" 28 : 8-13, 2005

      21 Bremner WJ, "Loss of circadian rhythmicity in blood testosterone levels with aging in normal men" 56 : 1278-1281, 1983

      22 Harman SM, "Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging" 86 : 724-731, 2001

      23 Luo L, "Leydig cell aging: steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme" 22 : 149-156, 2001

      24 Gray GD, "Hormonal changes and sexual function in aging men" 57 : 71-77, 1983

      25 Pincus SM, "Effects of age on the irregularity of LH and FSH serum concentrations in women and men" 273 : 989-995, 1997

      26 Barberia JM, "Diurnal variations of plasma testosterone in men" 22 : 615-626, 1973

      27 Vittek J, "Direct radioimmunoassay (RIA) of salivary testosterone, correlation with free and total serum testosterone" 37 : 711-716, 1985

      28 Goncharov N, "Diagnostic significance of free salivary testosterone measurement using a direct luminescence immunoassay in healthy men and in patients with disorders of androgenic status" 9 : 111-122, 2006

      29 Carnegie C, "Diagnosis of hypogonadism : clinical assessments and laboratory tests" 6 : 3-8, 2004

      30 Li JY, "Decline of serum levels of free testosterone in aging healthy Chinese men" 8 : 203-206, 2005

      31 Morley JE, "Comparison of screening questionnaires for the diagnosis of hypogonadism" 20 : 424-429, 2006

      32 Vermeulen A, "Clinical review 24—androgens in the aging male" 73 : 221-224, 1991

      33 Marrama P, "Circadian rhythm of testosterone and prolactin in the ageing" 4 : 131-138, 1982

      34 Jinrui H, "Changes in the salivary testosterone level in aged" 40 : 807-811, 1994

      35 Matsumoto AM, "Andropause: Clinical implications of the decline in serum testosterone levels with aging in men" 57 : 76-99, 2002

      36 Kaufman E, "Analysis of saliva for periodontal diagnosis" 27 : 453-465, 2000

      37 Chen H, "Age-related decreases in Leydig cell testosterone production are not restored by exposure to LH in vitro" 143 : 1637-1642, 2002

      38 Nahoul K, "Age-related decline of plasma bioavailable testosterone in adult men" 35 : 293-299, 1990

      39 Kang YG, "Age-related change in serum concentrations of testosterone in middle-aged Korean men" 6 : 8-12, 2003

      40 Neaves WB, "Age-related change in numbers of other interstitial cells in testes of adult men: evidence bearing on the fate of Leydig cells lost with increasing age" 33 : 259-269, 1985

      41 Gray A, "Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study" 73 : 1016-1025, 1991

      42 Zumoff B, "Age variation of the 24-hour mean plasma concentrations of androgens, estrogens, and gonadotropins in normal adult men" 54 : 534-538, 1982

      43 Feldman HA, "Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study" 87 : 589-598, 2002

      44 Veldhuis JD, "Age diminishes the testicular steroidogenic response to repeated intravenous pulses of recombinant human LH during acute GnRH-receptor blockade in healthy men" 288 : 775-781, 2005

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      2021-01-01 평가 등재학술지 유지 (재인증) KCI등재
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      2009-01-01 평가 등재후보학술지 유지 (등재후보2차) KCI등재후보
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      2007-01-01 평가 등재후보학술지 유지 (등재후보1차) KCI등재후보
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