위선종과 화생성 점막간의 연속적 추이 이석을 위한 초미세구조적 속성분석 = Ultrastructural Study of Gastric Adenomas - Morphological Evidences of Sequential Evolution from Preceding Intestinal Metaplastic Epithelium -

다국어 초록 (Multilingual Abstract)

To clarify the cellular characteristics of gastric adenoma and its evidence of sequential evolution from intestinal metaplastic change, 15 endoscopic biopsy and gastrectomy specimens of gastric adenomas were subjected to the ultrastructural investigation and were compared with 18 metaplastic mucosa of intestinal type and l2 adenocarcinomas of the stomach. 1) Ultrastructural features of gastric adenoma were similar to those of metaplastic epithelium of intestinal type in their cytoplasmic process and intracytoplasmic organelles. 2) Developmental pattern of microvilli and their allied structures in gastric adenomas resembled that in metaplastic epithelium of intestinal type. 3) Intestinal type of adenocsrcinoma of the stomach demonstrated 2 quantitatively different patterns of organellar distribution, but gastric adenoma followed the one with increased organelles, and it was more evident in mitochondria by demonstration of increased number together with higher osmiophilia. 4) Admixture of goblet cells, Paneth cells and enterochromaffin cells of varying stages within the adenomatous lesion was a frequent association so as advanced degree of metaplastic change in background mucosa. 5) Mitochondrial alterations were indicative of benign neoplastic properties than dysplastic epithelium. With the above features it is assumed that gastric lesion, formerly called dysplastic or borderline epithelium, lies between metaplastic epithelium and adenocarcinoma, and demonstrates a benign neoplastic property which arises from the preceding metaplastic change of gastric mucosa.