체강액의 세포학 = The Cytopathology of Body Cavity Fluid

다국어 초록 (Multilingual Abstract)

Cytologic examination of the body cavity fluid is very important because the specimens represent a significant percentage of nongynecologic samples and this cytologic examination may be the first, best or only chance for making the diagnosis of an underlying malignancy. The purposes of body cavity fluid examination are to correctly identify cancer cells and if possible, to identify the tumor types and primary sites when presented with unknown primary tumor sites. The most important basic differential diagnosis is that of benign and reactive disease vs malignant disease. Reactive mesothelial cells are a consistent population in body cavity fluid, and these are the most versatile cells in the body. Due to the specific environment of the body cavity, the exfoliated reactive mesothelial cells may show significant morphologic overlap with the morphology of cancer cells. With a focus on the differential points between reactive mesothelial cells and metastatic adenocarcinoma cells, the practical diagnostic approaches, the diagnostic clues and the pitfalls to achieve a correct diagnosis are presented in this review.

참고문헌 (Reference)

1 최수임, "장액성 삼출액의 도말 표본에서 반응성 중피세포와 샘암종 세포의 감별에 중피세포 표지자의 유용성" 대한세포병리학회 17 (17): 108-115, 2006

2 Churg A, "Tumors of the serosal membranes. AFIP atlas of tumor pathology"

3 Pereira TC, "The diagnosis of malignancy in effusion cytology: A pattern recognition approach" 13 : 174-184, 2006

4 Mohanty SK, "Serous effusions: diagnosis of malignancy beyond cytomorphology. An analytic review" 79 : 569-574, 2003

5 Choi YD, "Immunocytochemical panel for distinguishing between adenocarcinomas and reactive mesothelial cells in effusion cell blocks" 39-, 2008

6 Moriaty AT, "Fluids-Good and Bad Actors. Observation from the College of American Pathologists interlaboratory comparison program in nongynecoloic cytology" 128 : 513-518, 2004

7 Motherby H, "Diagnostic accuracy of effusion cytology" 20 : 350-357, 1999

8 Shidham VB, "Cytopathologic Diagnosis of Serous Fluids" Saunders-Elsevier 2007

9 Cibas ES, "Cytology. Diagnostic principles and clinical correlates" Saunders-Elsevier 119-144, 2007

10 Wilbur DC, "Body cavity fluid examination: Problem patterns and their resolution"