GABA agonist와 antagonist의 주입이 닭의 monocular Optokinetic nystagmus(OKN)에 미치는 영향 = Effects on the chicken monocular OKN of intravitreal injection of GABA agonist and antagonist

다국어 초록 (Multilingual Abstract)

Chicken monocular head and eye optokinetic nytagmus(OKN) were observed by coil recording after intravitreal administration of GABA agonist(THIP) and antagonist (SR95531) into the open and closed eye. Before injection of drugs the chicken displayed an OKN for T-N stimulation being more efficient in evoking this visuomotor reflex than N-T stimulation. The injection of GABA agonist(THIP) into either the open or closed eye induced a decrease of the head and eye OKN. On the other hand, the injection of GABA antagonist(SR 95531) into the closed eye, the head and eye OKN evoked an increase whereas the injection of GABA antagonist(SR 95531) into the open eye, the head and eye OKN provoked a decrease or disappearance. Thus, GABA antagonist abolished the directional asymmetry of the head and eye OKN, indicating the involvement of GABAergic mechanisms in the inhibition of the N-T component of the monocular OKN.