통년성 알레르기비염 환자에서 혈장 MCP-1, RANTES, IL-18 농도 = Plasma Level of MCP-1, RANTES, and IL-18 in Perennial Allergic Rhinitis Patients

다국어 초록 (Multilingual Abstract)

Background and Objectives：Plasma levels of MCP-1, RANTES and IL-18 are related to allergic diseases such as atopic der-of these cytokines and allergic rhinitis. Subjects and Method：The concentrations of plasma MCP-1, RANTES and IL-18 were analyzed by ELISA. The levels of cytokines were compared betwen perenial allergic rhinitis patients (n= 48) and controls (n= 33), and this depended on symptom severity. Results：Plasma levels of MCP-1 and IL-18 were significantly increased more in allergic rhinitis patients (MCP-1, 108 pg/mL, p<0.01；IL-18, 299 pg/mL, p<0.01) than in controls (MCP-1, 86 pg/mL；IL-18, 168 pg/mL). Especially, the levels of moderate-severe allergic rhinitis group (MCP-1, 116 pg/mL；IL-18, 329 pg/mL) showed higher tendency than mild one (MCP-1, 101 pg/mL；IL-18, 273 pg/mL). However, the levels of RANTES did not exhibit any diferences betwen allergic rhinitis and control. Conclusion：Our results suggest that plasma MCP-1 and IL-18 might be asso-(Korean J Otorhino -laryngol-Head Neck Surg 2007 ;50 :1103-8)

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