형질전환동물 기법을 이용한 질환동물모델의 활용 = Animal Model for Human Disease by Transgenic Techniques

다국어 초록 (Multilingual Abstract)

Introduction of gene into the germ line of mammals is one of the major recent technology advances in the area of biomedical sciences. Thrasgenic animals have been instrumental in providing new insight into mechanism of gene regulation, and also into the action of oncogenes. Furthermore, the transgenic technology offers exciting possibilities for generating precise animal models for human genetic disease. Transgenic mice expressing each human mutant PS2 gene and APPsw gene under the control of neuron-specific enolase (NSE) promoter, HPV16 E6 oncogene under the control of β-casein gene promoter, and CYP1B1 gene under the control of tetracycline regulator systems were produced in our laboratory. These transgenic mice offer new opportunities to investigate the evaluation and caracteristics of Alzheimer's disease and mammary gland tumor cellular abnormalities and also the effects of toxins, as well as biochemical and cellular mechanism of disease, and, ultimately, will provide systems to test therapeutic strategies.