<P>Silicon nanowires (SiNWs) offer promising inorganic nanostructures for biomedical application. Here, we report the development of a novel SiNW array designed for isolating primary CD4<SUP>+</SUP> T lymphocytes from the heterogeneo...
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https://www.riss.kr/link?id=A107622441
2010
-
SCI,SCIE,SCOPUS
학술저널
2877-2883(7쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>Silicon nanowires (SiNWs) offer promising inorganic nanostructures for biomedical application. Here, we report the development of a novel SiNW array designed for isolating primary CD4<SUP>+</SUP> T lymphocytes from the heterogeneo...
<P>Silicon nanowires (SiNWs) offer promising inorganic nanostructures for biomedical application. Here, we report the development of a novel SiNW array designed for isolating primary CD4<SUP>+</SUP> T lymphocytes from the heterogeneous mixture of cell populations. Our system employed the specific high-affinity binding features of streptavidin (STR)-functionalized SiNW with biotin-labeled CD4<SUP>+</SUP> T lymphocytes. Fabricated SiNW arrays easily separated the CD4<SUP>+</SUP> T lymphocytes from the mouse whole splenocytes with over ∼88% purity and demonstrated tight attachment to CD4<SUP>+</SUP> T lymphocytes by scanning electron microscopy. Thus, our STR-SiNW arrays provide a potential tool for specific cell separation and further present a possibility to be applied to the other area of biomedical applications.</P><P><B>Graphic Abstract</B>
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