Clinical effect of bovine amniotic membrane and hydrocolloid on laser wound: comparative, open label, randomized, clinical trial = Clinical effect of bovine amniotic membrane and hydrocolloid on laser wound: comparative, open label, randomized, clinical trial

다국어 초록 (Multilingual Abstract)

Background: Bovine amniotic membrane (BAM) accelerates epithelization, and have anti-inflammatory, anti-angiogenic and strong analgesic effects. Objectives: To evaluate the clinical effects of BAM on wound by ablative laser treatments and compare the clinical effect of BAM on wound with that of hydrocolloid dressing. Methods: Forty-nine subjects with nevi or scars requiring ablative laser treatment were enrolled. For comparing the efficacy, we divided the body into several areas such as face, neck, trunk, upper extremity and lower extremity and included the patients with two or more same skin lesions in the same area of the body. After ablative laser treatments, BAM and hydrocolloid dressing were applied to wound. Objective and subjective assessment were done at baseline, 1, 4, 6, 8, 11, 13 days after treatment. Histologic change was assessed by skin biopsy. Results: The site treated by BAM showed shorter epithelization time than hydrocolloid site (6.7 Vs 9.2 days). Epithelialization was confirmed by skin biopsy. Erythema and oozing at BAM-treated site after laser treatment faded away more quickly than those at hydrocolloid-treated site. Satisfaction score of BAM treatment was higher than that of hydrocolloid treatment. No adverse effects other than mild pruritus were observed. Immunohistochemistry revealed different growth factor profile between two treatment modalities. Conclusion: BAM could make benefits on wound by ablative laser treatment compared with hydrocolloid dressing.