Epstein-Barr Virus(EBV) 와 사람의 腫瘍

다국어 초록 (Multilingual Abstract)

Recently the evidence for an association between herpesviruses and neoplasia was rapidly accumulated. Herpesviruses are the only DNA viruses which have been associated with spontaneous malignancies in man. A herpesvirus has been well shown to be the epidemic cause of Marek's disease of fowl, and other herpesviruses also have been suspected or known to be oncogenic in man or other animals. Since the first observation of Epstein et al. (1964) of an unknown herpes-type virus, now referred to a Epstein-Barr virus (EBV), in cultured Burkitt lymphoma cells, the putative role of this virus in human carcinogenesis has been well documented. EBV appears.to meet several of the criteria, Burkitt lymphoma (BL), nasopharyngeal carcinoma (NPC) and infectious mononucleosis (IM), for an oncogenic virus. I believed that a comparative approach on diseases caused by oncogenic herpesviruses would be useful and of mutual value for the investigators. The current state of knowledge on EBV and associated laboratory techniques was briefly reviewed.