ICR 생쥐에서 엉겅퀴 잎 추출물의 항우울 효과 = The Antidepressant Effects of Cirsium japomicum in ICR Mice

다국어 초록 (Multilingual Abstract)

The antidepressant effects of Cirsium japonicum compositae was investigated using open field test and forced swimming test. Total extract of Cirsium japonicum (CJ) was orally administered at dose of 20, 100, 300, 500mg/kg body weight. Supplementation of CJ increase dose-dependently movement, rearing frequency and total turn angle in the center area of open field in mice. Treatment of Cirsium japonicum's extract (360mg/kg, CJ) decreased immobile duration and increased mobile and strong mobile duration significantly, and it is comparable to that of imipramine and fluoxetine. These results indicate that CJ has antidepressant effect. Treatment of CJ did not induced any impairment in motor coordination and myorelaxation. These results indicate that the constituents or its complex of Cirsium japonicum could be a candidate of new antidepressant drug.

참고문헌 (Reference)

1 "산야초 여행" 석오출판사 32-, 1988

2 "산나물의 재배와 이용법" 오성출판사 337-, 1987

3 "Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC" 6 : 1387-, 2006

4 "The use of silymarin in the treatment of liver diseases" 61 : 2035-, 2001

5 "The behavioral assessment of sensorimotor processes in the mouse In Methods of behavior analysis in neuroscience ed" CRC press LLC 27-50, 2001

6 "Studies on antihemmorrhagic substance in Herbs classified as hemo- statics in Chinese medicime On the antihemorrahgic principle in Cirsium japonicum DC" 35 : 861-, 1987

7 "Stress-reducing effects of brown rice koji" 15 : 63-, 2006

8 "Simple pharmacological test battery to assess efficacy and side effect profile of centrally acting muscle relaxant drugs" 52 : 264-, 2005

9 "Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver" 9 : 105-, 1989

10 "Psychopharmacology" Sinauer associates Inc 409-438, 2005

11 "Prevention of CCl4 induced cirrhosis by silymarin" 3 : 183-, 1989

12 "Phytochemical constituents of Cirsium setidens Nakai and their cytotoxicity against human cancer cell lines" 25 : 628-, 2002

13 "Korean Folk Medicine." Seoul National University Press 145-146, 1966

14 "Flavonoid compounds from the flowers of Cirsium rivulare" 60 : 87-, 2003

15 "Effects of methanol extract of Cirsium japonicum var hispidulin-7-O-neohesperidoside on hepatic alcohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats" 18 : 19-, 2004

16 "Effect of polyacetylenes oh the neurite outgrouwth of neuronal culture cells and scopolamine-induced memory impairment in mice" 24 : 1434-, 2001

17 "Effect of Cirsium pascuarense on blood glucose levels of normogly- caemic and alloxan-diabetic mice" 15 : 552-, 2001

18 "Centrilobular expression of ethanol-inducible cytochrome P450 (IIE1) in rat liver" 157 : 55-, 1988

19 "Behavioral despair in mice a primary screening test for antidepressants" 1977

20 "Batch solvent extraction of flavanolignans from milk thistle (Silybum marianum L. Gaertner)." 16 : 7-, 2005

21 "Apigenin modulates GABAergic and glutamatergic transmission in cultured cortical neurons" 502 : 41-, 2004

22 "Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways." 19 : 3423-, 2005

23 "Antimicrobial activity and cytotoxicity of Cirsium tenoreanum" 75 : 577-, 2004

24 "Antidepressant-like effect of lectin from Canavalia brasiliensis administered centrally in mice" 85 : 160-, 2006

25 "Antidepressant effect of Sayuksan and its influence on monoamines of depression model rats" 19 : 71-, 2004

26 "Anti-stress effect of Pyroligneous liquid in SD rats and ICR mice" 11 : 249-, 2003

27 "A versatile video tracking system for automation of behavioral experiments" 33 : 398-, 2001

28 "A polyacetylene and flavonoids from Cirsium rhinoceros" 26 : 128-, 2003

29 "A comparative study of the analgesic and anti-inflammatory activities of pectolanarin isolated from Cirsium subcoriaceum and linarin isolated from Buddleia cordata" 64 : 134-, 1998