Lipopolysaccharide(LPS)가 Lymphokine 생산에 미치는 影響에 관한 연구 = Studies on the Effects of Lipopolysaccharide(LPS) to the Lymphokine Production

다국어 초록 (Multilingual Abstract)

In order to evaluate the effects of LPS on the lymphokine production, the change of the levels of IL-2, γIFN and IL-4 meassured in splenocytes of C3H/HeN mice treated with E.coli LPS, S.abortus equi LPS and heated LPS.
The results were as follows;
1. The splenocytes isolated from LPS-injected mice produce greatly reduced levels of the T-cell lymphodine IL-2 and γIFN following activation in vitro with the polyclonal T-cell stimulant anti-CD3 and the production of IL-4 elevated in comparison to normal cotrols.
2. The levels of IL-2 and γIFN in the mice were treated with 5μg-LPS for 3 days elevated and IL-4 reduced continuously from one day later and the levels of 3 kinds lymphokine recovered to a normal value 13 days later.
3. The levels of IL-2 and γIFN in the mice were treated with 5μg-LPS for consecutive 2 weeks reduced and IL-4 elevated greatly at 3 days and the levels of 3 kinds lymphokine recovered to normal value 2 weeks later.
4. In the mice were treated with E.coli LPS and S.aboruts equi LPS, the change of the levels of IL-2, γIFN and IL-4 were not difference between E.coli LPS injected group and S.atortus equi infected group.
5. In the mice were treated with normal LPS and heated LPS, the change of the levels of IL-2, γIFN and IL-4 were not difference between normal LPS injected group and heated LPS injected group.