대장암은 우리나라에서 가장 급격하게 발생이 증가하는 암종의 하나로 유전성 대장암은 전체 대장암의 5-15%를 차지한다. 유전성 대장암은 크게 유전성 비용종증 대장암과 유전성 용종 증후...
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https://www.riss.kr/link?id=A82587088
2010
-
517
KCI등재후보
학술저널
24-36(13쪽)
3
0
상세조회0
다운로드국문 초록 (Abstract)
대장암은 우리나라에서 가장 급격하게 발생이 증가하는 암종의 하나로 유전성 대장암은 전체 대장암의 5-15%를 차지한다. 유전성 대장암은 크게 유전성 비용종증 대장암과 유전성 용종 증후...
대장암은 우리나라에서 가장 급격하게 발생이 증가하는 암종의 하나로 유전성 대장암은 전체 대장암의 5-15%를 차지한다. 유전성 대장암은 크게 유전성 비용종증 대장암과 유전성 용종 증후군에서 발생하는 대장암으로 나눌 수 있고, 유전성 용종 증후군에는 가족성 용종증, 포이츠-예거 증후군, 유년기 용종증, MYH 연관 용종증 등이 이에 해당한다. 유전성 대장암은 원인 유전자의 배선돌연변이에 기인하므로 산발성 대장암에 비하여 암이 조기 발생하고, 동시성 및 이시성 암이 흔하며, 대장 이외의 장기에도 종양을 비롯한 질병을 일으키는 특징이 있다. 유전성 대장암은 환자뿐 아니라 가족구성원에 대한 유전자 검사, 유전 상담, 조기 진단을 위한 정기 검진이 매우 중요하며, 이러한 환자 및 가족구성원의 효율적 관리를 위한 유전성종양 등록소의 역할이 중요하다. 본 논문에서는 유전성 대장암에 해당하는 질환들의 임상적/유전적 특성, 치료, 유전자 검사 및 정기검진 프로그램에 대하여 고찰하고자 한다.
다국어 초록 (Multilingual Abstract)
Colorectal cancer is one of the most steeply increasing malignancies in Korea. Among 398,824 new patients recorded by the Korea Central Cancer Registry between 2003 and 2005, 47,915 cases involved colorectal cancers, accounting for 12.0 % of all malig...
Colorectal cancer is one of the most steeply increasing malignancies in Korea. Among 398,824 new patients recorded by the Korea Central Cancer Registry between 2003 and 2005, 47,915 cases involved colorectal cancers, accounting for 12.0 % of all malignancies. In 2002, total number of colorectal cancer cases had accounted for 11.2 % of all malignancies. Hereditary syndromes are the source of approximately 5% to 15% of overall colorectal cancer cases. Hereditary colorectal cancers are divided into two types: hereditary nonpolyposis colorectal cancer (HNPCC), and cancers associated with hereditary colorectal polyposis, including familial adenomatous polyposis (FAP), Peutz-Jeghers syndrome, juvenile polyposis, and the recently reported hMutYH (MYH)-associated polyposis (MAP). Hereditary colorectal cancers have unique clinical features distinct from sporadic cancer because these are due to germline mutations of the causative genes; (ⅰ) early age-of-onset of cancer, (ⅱ) frequent association with synchronous or metachronous tumors, (ⅲ) frequent association with extracolonic manifestations. The management strategy for patients with hereditary colorectal cancer is quite different from that for sporadic cancer. Furthermore, screening, genetic counseling, and surveillance for at-risk familial member are also important. A well-organized registry can plays a central role in the surveillance and management of families affected by hereditary colorectal cancers. Here, we discuss each type of hereditary colorectal cancer, focusing on the clinical and genetic characteristics, management, genetic screening, and surveillance.
목차 (Table of Contents)
참고문헌 (Reference)
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Cognitive Profile of Children with Williams Syndrome
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2028 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2022-01-01 | 평가 | 등재학술지 유지 (재인증) | ![]() |
2020-06-02 | 학술지명변경 | 한글명 : 대한의학유전학회지 -> Journal of Genetic Medicine | ![]() |
2019-01-01 | 평가 | 등재학술지 선정 (계속평가) | ![]() |
2018-12-01 | 평가 | 등재후보로 하락 (계속평가) | ![]() |
2017-01-03 | 학회명변경 | 영문명 : The Korean Society of Medical Genetics -> The Korean Society of Medical Genetics and Genomics | ![]() |
2015-01-01 | 평가 | 등재학술지 선정 (계속평가) | ![]() |
2013-01-01 | 평가 | 등재 1차 FAIL (등재후보1차) | ![]() |
2012-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | ![]() |
2010-01-01 | 평가 | 등재후보학술지 선정 (신규평가) | ![]() |
2006-07-31 | 학회명변경 | 영문명 : Korean Society of Medical Genetics -> The Korean Society of Medical Genetics |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0 | 0 | 0 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.03 | 0.05 | 0 | 0 |